Graduate Institute of Sports Science, National Taiwan Sport University, Taoyuan, Taiwan.
Department of Exercise and Health Science, National Taipei University of Nursing and Health Sciences, Taipei, Taiwan.
Obes Facts. 2021;14(3):306-319. doi: 10.1159/000516865. Epub 2021 Jun 2.
Obesity, which can result from disease, genetics, nutrition, lifestyle, and insufficient physical activity, substantially increases an individual's risk of complications and comorbidities. Exercise can be an effective strategy for achieving an energy balance and physiological fitness as part of obesity management. Additionally, probiotics, which are isolated from food and the environment, are being rapidly developed and have functional benefits for mitigating various metabolic dysfunctions associated with obesity. The potentially positive physiological and functional effects of exercise, probiotics, and exercise combined with probiotics should be elucidated in a model of diet-induced obesity.
Bifidobacterium longum subsp. longum OLP-01 (OLP-01) was isolated from an elite Olympic-level athlete who exhibited physiological adaptations to peripheral fatigue caused by exercise training. In this current study, ICR strain mice were fed a high-fat diet (HFD) for 4 weeks to replicate an obesity model. The mice were divided into 5 groups according to the diet administered: control with normal diet, only HFD, HFD + exercise, HFD + OLP, and HFD + exercise + OLP groups. They were administered the probiotic and/or treadmill exercise training for 5 weeks, and their growth curve, physical activity, physiological adaptation, biochemical parameters, body composition, and glucose tolerance were assessed.
Compared with only exercise or only probiotics, a combination of probiotics and exercise significantly improved the weight, glucose tolerance, fat composition, and exercise-related oxidative stress of mice. Regular and programmed exercise with sufficient rest may be crucial to obesity improvement, and a combination of probiotics and exercise may synergistically assist obesity management and health promotion.
OLP-01 probiotics combined with exercise training can be employed as a strategy for treating obesity. However, the exact regulatory mechanisms underlying this effect, possibly involving microbiota and associated metabolites, warrant further investigation.
肥胖可由疾病、遗传、营养、生活方式和运动量不足等多种因素引起，会极大地增加个体出现并发症和合并症的风险。运动作为肥胖管理的一部分，可以是实现能量平衡和生理适应的有效策略。此外，益生菌是从食物和环境中分离出来的，正在被迅速开发，并具有减轻与肥胖相关的各种代谢功能障碍的功能益处。在饮食诱导的肥胖模型中，应该阐明运动、益生菌以及运动与益生菌联合应用的潜在积极生理和功能效应。
长双歧杆菌亚种 OLP-01（OLP-01）是从一位表现出对运动训练引起的外周疲劳生理适应的精英奥运级运动员的粪便中分离出来的。在本研究中，ICR 品系小鼠用高脂肪饮食（HFD）喂养 4 周，以复制肥胖模型。根据给予的饮食，将小鼠分为 5 组：正常饮食对照组、仅 HFD 组、HFD+运动组、HFD+OLP 组和 HFD+运动+OLP 组。它们接受益生菌和/或跑步机运动训练 5 周，评估其生长曲线、身体活动、生理适应、生化参数、身体成分和葡萄糖耐量。
与仅运动或仅益生菌相比，益生菌和运动的联合应用显著改善了小鼠的体重、葡萄糖耐量、脂肪组成和与运动相关的氧化应激。有规律和有计划的运动并充分休息可能对肥胖改善至关重要，益生菌和运动的联合应用可能协同辅助肥胖管理和促进健康。
OLP-01 益生菌联合运动训练可作为治疗肥胖的策略。然而，这种效应的确切调节机制，可能涉及微生物群及其相关代谢物，需要进一步研究。
