Clarke K W, Taylor P M
Equine Vet J. 1986 Sep;18(5):366-70. doi: 10.1111/j.2042-3306.1986.tb03655.x.
Detomidine, given intravenously at doses of 5 to 30 (mean 13) micrograms/kg bodyweight (bwt), provided adequate sedation for a variety of clinical procedures in 93 per cent of administrations, and improved the ease of handling in the remaining animals. Side effects of ataxia and bradycardia were minimal at the lower dose rates. Higher doses were required for intramuscular use. In experimental trials 10 and 20 micrograms/kg bwt resulted in deep sedation and also significant hypertension and bradycardia of over 15 mins duration. Current literature on the use of detomidine in horses is reviewed.
静脉注射剂量为5至30（平均13）微克/千克体重的地托咪定，在93%的给药中为各种临床操作提供了足够的镇静作用，并使其余动物的处理更加容易。在较低剂量率下，共济失调和心动过缓的副作用最小。肌肉注射需要更高的剂量。在实验试验中，10和20微克/千克体重导致深度镇静，还导致持续超过15分钟的显著高血压和心动过缓。本文综述了目前关于马使用地托咪定的文献。
