Verkuijl Sabine, Sekadde Moorine Penninah, Dodd Peter J, Arinaitwe Moses, Chiang Silvia S, Brands Annemieke, Viney Kerri, Sismanidis Charalambos, Jenkins Helen E
Global Tuberculosis Programme, World Health Organization, 1211 Geneva, Switzerland.
National Tuberculosis and Leprosy Programme, Kampala 7025, Uganda.
Pathogens. 2022 Mar 14;11(3):352. doi: 10.3390/pathogens11030352.
The burden of tuberculosis (TB) among children and young adolescents (<15 years old) is estimated at 1.1 million; however, only 400,000 are treated for TB, indicating a large gap between the number who are cared for and the number estimated to have TB. Accurate data on the burden of pediatric TB is essential to guide action. Despite several improvements in estimating the burden of pediatric TB in the last decade, as well as enhanced data collection efforts, several data gaps remain, both at the global level, but also at the national level where surveillance systems and collaborative research are critical. In this article, we describe recent advances in data collection and burden estimates for TB among children and adolescents, and the remaining gaps. While data collection continues to improve, burden estimates must evolve in parallel, both in terms of their frequency and the methods used. Currently, at the global level, there is a focus on age-disaggregation of TB notifications, the collection of data on TB-HIV, multi-drug resistant (MDR)-TB and treatment outcomes, as well as estimates of the disease burden. Additional data from national surveillance systems or research projects on TB meningitis, as well as other forms of extra-pulmonary TB, would be useful. We must capitalize on the current momentum in child and adolescent TB to close the remaining data gaps for these age groups to better understand the epidemic and further reduce morbidity and mortality due to TB.
据估计,儿童和青少年(<15岁)的结核病负担为110万;然而,只有40万结核病患儿接受了治疗,这表明接受治疗的人数与估计患结核病的人数之间存在巨大差距。准确的儿童结核病负担数据对于指导行动至关重要。尽管在过去十年中,儿童结核病负担估计有了一些改进,数据收集工作也得到加强,但在全球层面以及国家层面仍存在一些数据缺口,在国家层面,监测系统和合作研究至关重要。在本文中,我们描述了儿童和青少年结核病数据收集和负担估计的最新进展以及仍然存在的差距。虽然数据收集工作在不断改进,但负担估计必须在频率和使用的方法方面同步发展。目前,在全球层面,重点是结核病通报的年龄分类、结核病-艾滋病病毒、耐多药结核病和治疗结果的数据收集,以及疾病负担的估计。来自国家监测系统或关于结核性脑膜炎以及其他肺外结核形式的研究项目的更多数据将很有用。我们必须利用目前儿童和青少年结核病方面的势头,填补这些年龄组仍然存在的数据缺口,以便更好地了解疫情,并进一步降低结核病的发病率和死亡率。