Yu Xiaoying, Saphire Erica Ollmann
Center for Infectious Disease and Vaccine Discovery, La Jolla Institute for Immunology, 9420 Athena Circle, La Jolla, CA 92037, USA.
Department of Medicine, University of California, San Diego, La Jolla, CA 92093, USA.
Pathogens. 2022 Mar 18;11(3):374. doi: 10.3390/pathogens11030374.
The filoviruses, including ebolaviruses and marburgviruses, are among the world's deadliest pathogens. As the only surface-exposed protein on mature virions, their glycoprotein GP is the focus of current therapeutic monoclonal antibody discovery efforts. With recent technological developments, potent antibodies have been identified from immunized animals and human survivors of virus infections and have been characterized functionally and structurally. Structural insight into how the most successful antibodies target GP further guides vaccine development. Here we review the recent developments in the identification and characterization of neutralizing antibodies and cocktail immunotherapies.
丝状病毒，包括埃博拉病毒和马尔堡病毒，是世界上最致命的病原体之一。作为成熟病毒粒子上唯一暴露于表面的蛋白质，其糖蛋白GP是当前治疗性单克隆抗体研发工作的重点。随着近期技术的发展，已从免疫动物和病毒感染的人类幸存者中鉴定出强效抗体，并对其进行了功能和结构表征。对最成功的抗体如何靶向GP的结构洞察进一步指导了疫苗开发。在此，我们综述了中和抗体及联合免疫疗法鉴定与表征方面的最新进展。
