Pagano Cinzia, Luzi Francesca, Ricci Maurizio, Michele Alessandro Di, Puglia Debora, Ceccarini Maria Rachele, Beccari Tommaso, Blasi Francesca, Cossignani Lina, Schoubben Aurélie, Primavilla Sara, Iborra César Antonio Viseras, Perioli Luana
Department of Pharmaceutical Sciences, University of Perugia, 06123 Perugia, Italy.
Department of Materials, Environmental Sciences and Urban Planning (SIMAU), 60131 Ancona, Italy.
Pharmaceutics. 2022 Feb 22;14(3):485. doi: 10.3390/pharmaceutics14030485.
The success of wound treatment is conditioned by the combination of both suitable active ingredients and formulation. Grape seed extract (GSE), a waste by-product obtained by grape processing, is a natural source rich in many phenolic compounds responsible for antioxidant, anti-inflammatory, and antimicrobial activities and for this reason useful to be used in a wound care product. Bioadhesive polymeric patches have been realized by combining acacia gum (AG) and polyvinylpyrrolidone (PVP). Prototypes were prepared by considering different AG/PVP ratios and the most suitable in terms of mechanical and bioadhesion properties resulted in the 9.5/1.0 ratio. This patch was loaded with GSE combined with cyclic dextrin (CD) to obtain the molecular dispersion of the active ingredient in the dried formulation. The loaded patch resulted mechanically resistant and able to release GSE by a sustained mechanism reaching concentrations able to stimulate keratinocytes' growth, to exert both antibacterial and antioxidant activities.
伤口治疗的成功取决于合适的活性成分与配方的结合。葡萄籽提取物（GSE）是葡萄加工过程中产生的一种废弃副产品，是一种天然来源，富含多种具有抗氧化、抗炎和抗菌活性的酚类化合物，因此可用于伤口护理产品。通过将阿拉伯胶（AG）和聚乙烯吡咯烷酮（PVP）结合，制备了生物粘附聚合物贴片。通过考虑不同的AG/PVP比例制备了原型，在机械性能和生物粘附性能方面最合适的比例为9.5/1.0。该贴片负载了与环糊精（CD）结合的GSE，以在干燥配方中获得活性成分的分子分散体。负载后的贴片具有机械抗性，能够通过持续释放机制释放GSE，达到能够刺激角质形成细胞生长、发挥抗菌和抗氧化活性的浓度。
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