Pérez Gutíerrez Carmen Laura, Di Michele Alessandro, Pagano Cinzia, Puglia Debora, Luzi Francesca, Beccari Tommaso, Ceccarini Maria Rachele, Primavilla Sara, Valiani Andrea, Vicino Camilla, Ricci Maurizio, Viseras Iborra César Antonio, Perioli Luana
Department of Pharmaceutical Sciences, University of Perugia, 06123 Perugia, Italy.
Department of Pharmacy and Pharmaceutical Technology, Faculty of Pharmacy, University of Granada, 18016 Granada, Spain.
Pharmaceutics. 2023 Jul 31;15(8):2057. doi: 10.3390/pharmaceutics15082057.
Hazelnut shells, the main waste deriving from hazelnut processing, represent an interesting source of active molecules useful in pharmaceutics, although they have not yet been examined in depth. A hydrosoluble extract (hazelnut shell extract, HSE) was prepared by the maceration method using a hydroalcoholic solution and used as the active ingredient of patches (prepared by casting method) consisting of composites of highly deacetylated chitosan and green clay. In vitro studies showed that the formulation containing HSE is able to stimulate keratinocyte growth, which is useful for healing purposes, and to inhibit the growth of (Log CFU/mL 0.95 vs. 8.85 of the control after 48 h); this bacterium is often responsible for wound infections and is difficult to treat by conventional antibiotics due to its antibiotic resistance. The produced patches showed suitable tensile properties that are necessary to withstand mechanical stress during both the removal from the packaging and application. The obtained results suggest that the developed patch could be a suitable product to treat wounds.
榛子壳是榛子加工产生的主要废料，尽管尚未对其进行深入研究，但它是制药领域中活性分子的一个有趣来源。采用水醇溶液浸渍法制备了一种水溶性提取物（榛子壳提取物，HSE），并将其用作由高度脱乙酰化壳聚糖和绿土复合材料制成的贴剂（通过流延法制备）的活性成分。体外研究表明，含有HSE的制剂能够刺激角质形成细胞生长，这对伤口愈合有益，并且能够抑制金黄色葡萄球菌的生长（48小时后，Log CFU/mL为0.95，而对照组为8.85）；这种细菌常导致伤口感染，并且由于其抗生素耐药性，难以用传统抗生素治疗。所制备的贴剂表现出合适的拉伸性能，这对于在从包装中取出和应用过程中承受机械应力是必要的。所得结果表明，所开发的贴剂可能是一种治疗伤口的合适产品。
