Seifert Ashley W, Temple-Smith Peter
Department of Biology, University of Kentucky, Lexington, KY, United States; Department of Veterinary Anatomy and Physiology, University of Nairobi, Nairobi, Kenya.
Department of Obstetrics & Gynecology, Monash University, Clayton, VIC, Australia.
Curr Top Dev Biol. 2022;147:659-707. doi: 10.1016/bs.ctdb.2021.12.017. Epub 2022 Feb 25.
Although certain organisms are chosen and employed to better understand a specific problem in biology (so-called model organisms), sometimes an animal model reveals its' biomedical importance by happenstance. In many ways, the advent of spiny mice (Acomys) as an emerging model to study regeneration and menstruation stands as a case study in scientific pseudoserendipity (Diaz de Chumaceiro, 1995). As we recount in this chapter, the discovery of these phenotypes, while not entirely accidental, was nonetheless unexpected. In addition to recounting how we uncovered these unusual mammalian traits, we outline recent work by our groups and others that has begun to outline the cellular and genetic mechanisms underlying bonafide mammalian tissue regeneration and a human-like mode of reproduction in spiny mice.
尽管会选择并使用某些生物体来更好地理解生物学中的特定问题（即所谓的模式生物），但有时动物模型会偶然间展现出其生物医学重要性。在许多方面，多刺小鼠（刺巢鼠属）作为研究再生和月经的新兴模型的出现，堪称科学假意外发现的一个案例研究（迪亚斯·德·丘马塞罗，1995年）。正如我们在本章中所述，这些表型的发现虽不完全是偶然的，但仍然出乎意料。除了讲述我们是如何发现这些不寻常的哺乳动物特征的，我们还概述了我们团队和其他团队最近的工作，这些工作已开始勾勒出多刺小鼠真正的哺乳动物组织再生和类人繁殖模式背后的细胞和遗传机制。
