Fujian Key Laboratory of Polymer Materials, College of Chemistry and Materials Science, Fujian Normal University, Fujian 350007, China.
Fujian Key Laboratory of Polymer Materials, College of Chemistry and Materials Science, Fujian Normal University, Fujian 350007, China.
Carbohydr Polym. 2022 Jun 15;286:119319. doi: 10.1016/j.carbpol.2022.119319. Epub 2022 Mar 5.
Development of efficient hemostatic gauze is critical to increasing survival rate by quick bleeding control of life-threatening hemorrhage. Herein, a novel chitosan non-woven hemostatic gauze is made by slightly surface modification with a special catechol compound, i.e. 3-(9,11,13-pentadecatrienyl)-1,2-benzenediol with a long side hydrophobic alkyl chain. Its wettability, interaction with red blood cell and platelet, and hemostatic efficacy on rat injuries are evaluated. This chitosan-catechol gauze demonstrates impressive hemostatic performances on rat femoral artery and liver laceration injury models (blood loss of this modified chitosan gauze is less than 17% of that of pristine chitosan gauze). Additionally, it is biodegradable, and maintains non-cytotoxicity. It integrates three structure and function effects together, i.e., anchoring effect between catechol and tissue, blood repelling effect from hydrophobic alkyl chain, and blood wicking effect from hydrophilic chitosan. Therefore, a new hemostatic mechanism is proposed for the excellent hemostatic potentials of this chitosan gauze.
开发高效的止血纱布对于提高因严重出血导致的死亡率至关重要。在此，我们通过轻微的表面改性，用一种特殊的儿茶酚化合物，即带有长侧疏水烷基链的 3-(9,11,13-十五碳三烯基)-1,2-苯二酚，制备了一种新型壳聚糖非织造止血纱布。我们评估了其润湿性、与红细胞和血小板的相互作用，以及在大鼠损伤模型中的止血效果。该壳聚糖-儿茶酚纱布在大鼠股动脉和肝脏撕裂伤模型中表现出了令人印象深刻的止血性能（这种改性壳聚糖纱布的失血量少于未改性壳聚糖纱布的 17%）。此外，它还具有生物可降解性和非细胞毒性。它将三种结构和功能效果结合在一起，即儿茶酚与组织之间的锚固效应、疏水烷基链的抗血液效应和亲水壳聚糖的吸血效应。因此，我们提出了一种新的止血机制来解释这种壳聚糖纱布具有优异的止血潜能。
