Department of Obstetrics and Gynecology, College of Medicine, Korea University Anam Hospital, Korea University, 73 Goryeodae-ro, Seongbuk-gu, Seoul 02841, South Korea.
Department of Obstetrics and Gynecology, College of Medicine, Korea University Anam Hospital, Korea University, 73 Goryeodae-ro, Seongbuk-gu, Seoul 02841, South Korea.
Maturitas. 2022 May;159:1-6. doi: 10.1016/j.maturitas.2021.12.005. Epub 2021 Dec 16.
To evaluate the association between vasomotor symptoms (VMS) and carotid intima-media thickness (CIMT) in Korean midlife women.
This cross-sectional study included 918 Korean women aged 45-65 years who attended their routine health checkup at a single institution between 2013 and 2016.
All participants' results on the Menopause Rating Scale were used to assess the VMS. Severe and very severe VMS were combined into severe VMS. CIMT and blood flow velocities were measured on the common carotid arteries using duplex ultrasound.
All participants' mean age was 54.73 ± 5.37 years, and 627 (68.3%) were postmenopausal. A total of 401 (43.7%) women reported VMS: 217 (23.6%), mild; 109 (11.9%), moderate; and 75 (8.2%), severe. The mean CIMT was 0.062 ± 0.017 mm and 0.064 ± 0.019 mm in premenopausal and menopausal women, respectively. In the multivariate linear regression analysis, the CIMT of women with moderate VMS was 0.102 mm (95% confidence interval [CI] = 0.002-0.009) more than that of women with no VMA, and the CIMT of women with severe VMS was 0.246 mm (95% CI = 0.012-0.021) more than that of women with no VMS, after adjusting for several confounders, including age, body mass index, and lifestyle factors. Severe VMS were associated with the risk of thickened CIMT (≥0.075 mm) and/or plaques (odds ratio = 2.90, 95% CI = 1.74-4.84) in the logistic regression analysis after adjusting for the same variables.
Moderate and severe VMS are independently associated with increased CIMT in otherwise healthy Korean midlife women. Clinicians managing midlife women with bothersome VMS should consider screening for subclinical cardiovascular diseases.
评估血管舒缩症状（VMS）与韩国中年女性颈动脉内膜中层厚度（CIMT）之间的关系。
这是一项横断面研究，纳入了 2013 年至 2016 年间在一家机构进行常规健康检查的 918 名年龄在 45-65 岁的韩国女性。
所有参与者的绝经评定量表结果用于评估 VMS。严重和非常严重的 VMS 合并为严重 VMS。使用双功能超声测量颈总动脉的 CIMT 和血流速度。
所有参与者的平均年龄为 54.73±5.37 岁，627 人（68.3%）处于绝经后状态。共有 401 名（43.7%）女性报告有 VMS：217 名（23.6%）为轻度；109 名（11.9%）为中度；75 名（8.2%）为重度。绝经前和绝经后女性的平均 CIMT 分别为 0.062±0.017mm 和 0.064±0.019mm。在多元线性回归分析中，中度 VMS 女性的 CIMT 比无 VMA 女性高 0.102mm（95%置信区间[CI]：0.002-0.009），重度 VMS 女性的 CIMT 比无 VMS 女性高 0.246mm（95%CI：0.012-0.021），校正年龄、体重指数和生活方式等多种混杂因素后。在调整相同变量的逻辑回归分析中，严重 VMS 与 CIMT 增厚（≥0.075mm）和/或斑块（比值比[OR]：2.90，95%CI：1.74-4.84）的风险相关。
在其他健康的韩国中年女性中，中度和重度 VMS 与 CIMT 增加独立相关。管理有明显 VMS 的中年女性的临床医生应考虑筛查亚临床心血管疾病。
