Chen Wenwen, Lu Sujuan, Lin Min, Chen Kun, Huang Feng
Shengli Clinical Medical College of Fujian Medical University, Fuzhou, China.
Department of Geriatric Medicine, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, China.
Front Public Health. 2025 May 22;13:1561920. doi: 10.3389/fpubh.2025.1561920. eCollection 2025.
Ethylene oxide (EO) is a toxic compound extensively used in industrial applications. This study quantified serum EO levels by measuring hemoglobin-bound ethylene oxide (HbEO). However, the link between bone mineral density (BMD) and HbEO levels remains unexplored.
A total of 2,570 participants were evaluated using data from National Health and Nutrition Examination Survey (NHANES) (2015-2018). Generalized linear regression models (LRM) and restricted cubic spline (RCS) analyses were used to investigate the association between blood EO levels and BMD. Adjusted models were also applied for comprehensive analysis.
Blood EO levels and BMD were inversely related ( = 0.007). This RCS analysis also showed an L-shaped dose-response correlation between EO levels and BMD ( for nonlinearity <0.001).
This study highlights a substantial correlation between EO exposure and BMD. Further randomized controlled trials are required to establish a causal relationship.
环氧乙烷（EO）是一种广泛应用于工业领域的有毒化合物。本研究通过测量血红蛋白结合环氧乙烷（HbEO）来量化血清环氧乙烷水平。然而，骨密度（BMD）与HbEO水平之间的联系仍未得到探索。
使用来自国家健康与营养检查调查（NHANES）（2015 - 2018年）的数据对总共2570名参与者进行了评估。采用广义线性回归模型（LRM）和受限立方样条（RCS）分析来研究血液环氧乙烷水平与骨密度之间的关联。还应用了调整模型进行综合分析。
血液环氧乙烷水平与骨密度呈负相关（β = 0.007）。该RCS分析还显示环氧乙烷水平与骨密度之间呈L形剂量反应相关性（非线性检验P < 0.001）。
本研究突出了环氧乙烷暴露与骨密度之间的显著相关性。需要进一步的随机对照试验来建立因果关系。
