Department of Neurology, Center for Cognitive Neurology, Institute of Clinical Neurology, Fujian Medical University Union Hospital, 29 Xinquan Road, Fuzhou 350001, China; Fujian Institute of Geriatrics, Fujian Medical University Union Hospital, 29 Xinquan Road, Fuzhou 350001, China; cFujian Key Laboratory of Molecular Neurology, Fujian Medical University, 88 Jiaotong Road, Fuzhou 350001, China; Fujian medical University, Fuzhou, China.
Department of Neurology, Center for Cognitive Neurology, Institute of Clinical Neurology, Fujian Medical University Union Hospital, 29 Xinquan Road, Fuzhou 350001, China; Fujian Institute of Geriatrics, Fujian Medical University Union Hospital, 29 Xinquan Road, Fuzhou 350001, China; cFujian Key Laboratory of Molecular Neurology, Fujian Medical University, 88 Jiaotong Road, Fuzhou 350001, China; Fujian medical University, Fuzhou, China; Department of Neurosurgery, Fujian Medical University Union Hospital, 29 Xinquan Road, Fuzhou 350001, China.
J Affect Disord. 2024 Mar 1;348:135-142. doi: 10.1016/j.jad.2023.12.050. Epub 2023 Dec 26.
Ethylene oxide (EO) is a commonly used compound with known health risks. However, the specific association between EO exposure and the development of depressive symptoms has not been well established. Therefore, this study aimed to examine the potential association between EO exposure, as indicated by hemoglobin adduct of ethylene oxide (HbEO) levels, and the occurrence of depressive symptoms.
We employed logistic regression, restricted cubic spline, and subgroup analysis to investigate the association between EO exposure and the occurrence of depressive symptoms. Additionally, we conducted a mediating effect analysis to explore the potential factors influencing the association between EO exposure and depressive symptoms.
Elevated HbEO levels were associated with the development of depressive symptoms. After adjusting for potential confounders, the highest quartile of HbEO levels showed an odds ratio (OR) of 3.37 [95 % confidence interval (CI): 1.87-6.10, P = 0.002] compared with the lowest quartile. Additionally, a linear association was observed between HbEO levels and the risk of depressive symptoms. We also revealed that the levels of several inflammatory factors and triglycerides mediated the association between EO exposure and the occurrence of depressive symptoms.
Higher levels of EO exposure were related to an increased risk of developing depressive symptoms. The analysis also suggested that the inflammatory response might play a mediating role in the pathway from EO exposure to depressive symptoms.
环氧乙烷（EO）是一种常用化合物，具有已知的健康风险。然而，EO 暴露与抑郁症状发展之间的具体关联尚未得到充分确立。因此，本研究旨在探讨 EO 暴露（通过血红蛋白乙撑氧加合物水平表示）与抑郁症状发生之间的潜在关联。
我们采用逻辑回归、限制立方样条和亚组分析来研究 EO 暴露与抑郁症状发生之间的关联。此外，我们还进行了中介效应分析，以探讨影响 EO 暴露与抑郁症状之间关联的潜在因素。
较高的 HbEO 水平与抑郁症状的发生有关。在校正了潜在混杂因素后，HbEO 水平最高四分位数与最低四分位数相比，发生抑郁症状的比值比（OR）为 3.37（95%置信区间[CI]：1.87-6.10，P=0.002）。此外，HbEO 水平与抑郁症状风险之间呈线性关联。我们还发现，几种炎症因子和甘油三酯的水平介导了 EO 暴露与抑郁症状发生之间的关联。
较高的 EO 暴露水平与发生抑郁症状的风险增加有关。分析还表明，炎症反应可能在 EO 暴露与抑郁症状之间的途径中发挥中介作用。
