Institute of Clinical and Experimental Trauma Immunology, Ulm University Medical Center, Ulm, Germany.
Department of Trauma, Orthopedic, Plastic and Hand Surgery, University Hospital of Augsburg, Augsburg, Germany.
Cell Mol Life Sci. 2022 Mar 26;79(4):207. doi: 10.1007/s00018-022-04234-0.
Despite the manifold recent efforts to improve patient outcomes, trauma still is a clinical and socioeconomical issue of major relevance especially in younger people. The systemic immune reaction after severe injury is characterized by a strong pro- and anti-inflammatory response. Besides its functions as energy storage depot and organ-protective cushion, adipose tissue regulates vital processes via its secretion products. However, there is little awareness of the important role of adipose tissue in regulating the posttraumatic inflammatory response. In this review, we delineate the local and systemic role of adipose tissue in trauma and outline different aspects of adipose tissue as an immunologically active modifier of inflammation and as an immune target of injured remote organs after severe trauma.
尽管最近在提高患者预后方面做出了多方面的努力，但创伤仍然是一个具有重要临床和社会经济学意义的问题，尤其是在年轻人中。严重损伤后的全身免疫反应表现为强烈的促炎和抗炎反应。除了作为能量储存库和器官保护垫的功能外，脂肪组织还通过其分泌产物来调节重要的生理过程。然而，人们对脂肪组织在调节创伤后炎症反应中的重要作用知之甚少。在这篇综述中，我们描述了脂肪组织在创伤中的局部和全身作用，并概述了脂肪组织作为炎症的免疫活性调节剂以及作为严重创伤后受损远隔器官的免疫靶点的不同方面。
