Shandong Provincial Key Laboratory of Animal Biotechnology and Disease Control and Prevention, Department of Animal Science and Technology, Shandong Agricultural University, Taian, China.
Hebei Key Laboratory of Specialty Animal Germplasm Resources Exploration and Innovation, Department of Animal Science and Technology, Hebei Normal University of Science and Technology, Qinhuangdao, China.
J Sci Food Agric. 2022 Sep;102(12):5422-5428. doi: 10.1002/jsfa.11895. Epub 2022 Apr 12.
As major stress hormones, glucocorticoids can directly or indirectly affect the intestinal microflora, although few studies have focused on changes in the composition of the intestinal microflora. In this study, rabbits were randomly divided into two groups: gavage administration with saline, and the same doses of dexamethasone (1 mg kg ). After 7 days, the microbial diversity of the jejunum contents was analysed.
The gut microflora richness and diversity had no significant difference between the two groups. The proportions of Firmicutes and Bacteroidetes were the most abundant in the jejunum of meat rabbits. Dexamethasone injection led to a change in the structure of the gut microflora composition, and we found that there were six biomarkers with linear discriminant analysis score >4 (Firmicutes, Caproiciproducens, Clostridiales, Clostridia, Psychrobacter, and Psychrobacter faecalis), moreover, the results of this study provide new insight into alleviating the effects of stress on meat rabbits.
It was concluded that glucocorticoids caused changes in the composition of intestinal microflora. © 2022 Society of Chemical Industry.
作为主要的应激激素，糖皮质激素可以直接或间接影响肠道微生物群，尽管很少有研究关注肠道微生物群组成的变化。在这项研究中，兔子被随机分为两组：生理盐水灌胃组和相同剂量地塞米松（1mg/kg）灌胃组。7 天后，分析空肠内容物的微生物多样性。
两组间肠道微生物菌群丰富度和多样性无显著差异。厚壁菌门和拟杆菌门在肉兔空肠中含量最丰富。地塞米松注射导致肠道微生物群组成结构发生变化，我们发现有 6 个具有线性判别分析评分>4 的生物标志物（厚壁菌门、产丁酸梭菌、梭状芽胞杆菌目、梭菌纲、嗜冷杆菌属和粪嗜冷杆菌），此外，本研究结果为缓解应激对肉兔的影响提供了新的见解。
糖皮质激素引起了肠道微生物群组成的变化。 © 2022 英国化学学会。
