Faculté de médecine et des sciences de la santé, Université de Sherbrooke, Sherbrooke, QC, Canada; Centre de Recherche sur le Vieillissement, CIUSSS de l'Estrie-CHUS, Sherbrooke, QC, Canada.
Centre de Recherche sur le Vieillissement, CIUSSS de l'Estrie-CHUS, Sherbrooke, QC, Canada; Département de Psychologie, Université de Sherbrooke, Sherbrooke, QC, Canada.
Prostaglandins Leukot Essent Fatty Acids. 2022 Mar;178:102415. doi: 10.1016/j.plefa.2022.102415. Epub 2022 Mar 18.
To investigate whether omega-3 polyunsaturated fatty acids (n-3 PUFA) supplementation improve cognitive performance and if apolipoprotein E (APOE) genotype or age were effect modifiers.
Healthy adults of 20 to 80 years old (n = 193) were completed a 6-month double-blind randomized controlled trial with two groups: 2.5 g/day of n-3 PUFA or a placebo. Primary outcomes were visuospatial ability and working memory and secondary outcomes were episodic memory and executive function, measured at baseline and 6 months.
Cognitive performances did not significantly differ between groups on primary or secondary outcomes after 6 months of treatment. APOE carriers and age were not effect modifiers for any outcomes. Those with low episodic memory scores and taking the n-3 PUFA supplement, significantly improved their scores (p = 0.043).
A 6-month n-3 PUFA supplementation did not improve cognitive performance in cognitively healthy adults and APOE status or age were not effect modifiers.
研究 ω-3 多不饱和脂肪酸（n-3PUFA）补充是否能改善认知表现，以及载脂蛋白 E（APOE）基因型或年龄是否为影响因素。
20 至 80 岁的健康成年人（n=193）完成了一项为期 6 个月的双盲随机对照试验，分为两组：每天 2.5 克 n-3PUFA 或安慰剂。主要结局是视空间能力和工作记忆，次要结局是情景记忆和执行功能，在基线和 6 个月时测量。
经过 6 个月的治疗，两组在主要或次要结局上的认知表现没有显著差异。APOE 携带者和年龄对任何结果都不是影响因素。那些情景记忆评分较低且服用 n-3PUFA 补充剂的人，其评分显著提高（p=0.043）。
6 个月的 n-3PUFA 补充并没有改善认知健康成年人的认知表现，APOE 状态或年龄不是影响因素。
