固化方式对双固化树脂水门汀单体溶出、吸附和溶解性的影响。
Influence of curing modes on monomer elution, sorption and solubility of dual-cure resin-cements.
机构信息
Biomaterials Science, Division of Dentistry, School of Medical Sciences, University of Manchester, UK; Division of Dental Biomaterials Science, College of Dentistry, King Saud University, Saudi Arabia.
Biomaterials Science, Division of Dentistry, School of Medical Sciences, University of Manchester, UK.
出版信息
Dent Mater. 2022 Jun;38(6):978-988. doi: 10.1016/j.dental.2022.03.004. Epub 2022 Mar 24.
OBJECTIVE
To explore the effect of two curing modes, for dual-cure resin cements, on their monomer elution, water sorption and solubility after 30 d water storage and 30 d dry reconditioning.
METHODS
Eight dual-cure resin-cements were investigated (Bifix SE, Nexus Third Generation, PANAVIA SA, PANAVIA V5, RelyX Ultimate Universal, RelyX Unicem 2, RelyX Universal and SpeedCEM Plus). Six disk-shaped specimens were made per curing mode: light-cure (LC) versus self-cure (SC) to measure amounts of eluted monomers after 30 d of water storage at 37 °C. Ultra-high performance liquid chromatography tandem mass spectrometry (UHPLC MS/MS) was performed to identify and quantify three eluted monomers (Bis-GMA, UDMA and TEGDMA). Water sorption/ solubility specimens were prepared according to ISO 4049. Specimens from each curing mode (LC/SC) were immersed separately in distilled water for 30 d and then reconditioned for 30 d; all at 37 °C. Mass change was measured at different time intervals. Data were analyzed via one-way ANOVA, Tukey post-hoc tests and independent sample t-tests (α = 0.05).
RESULTS
After 30 d of water storage, the three monomers Bis-GMA, UDMA and TEGDMA were detected in water. All monomers showed a variable extent of elution into water and were significantly higher (p < 0.0001) with SC compared to LC curing modes. BSE had the highest quantity of eluted monomers. After 30 d of water sorption (μg/mm), all rein-cements showed significantly higher sorption (p < 0.05) of SC compared to LC curing modes except for PV5, RXU and CEM (p > 0.05). After 30 d of water solubility (μg/mm), all resin-cements showed significantly higher solubility (p < 0.0001) of SC compared to LC curing mode. BSE had the highest water sorption and solubility. The total amounts of eluted monomers correlated positively with solubility: r = 0.95 for LC and r = 0.93 for SC.
SIGNIFICANCE
Whenever light access is possible, light curing remains beneficial to reduce the extent of resin degradation and related properties of dual-cure resin cements. BSE showed statistically the highest extent of eluted monomers, sorption and solubility.
目的
探索两种固化模式（双固化树脂水门汀的光固化和自固化）对其单体洗脱、水吸附和溶出的影响，这些影响在 30d 水储存和 30d 干燥再处理后会出现。
方法
研究了 8 种双固化树脂水门汀（Bifix SE、Nexus 第三代、PANAVIA SA、PANAVIA V5、RelyX Ultimate Universal、RelyX Unicem 2、RelyX Universal 和 SpeedCEM Plus）。每种固化模式（光固化[LC]和自固化[SC]）各制作 6 个圆盘状试件，以测量 37°C 水储存 30d 后的洗脱单体量。采用超高效液相色谱串联质谱法（UHPLC-MS/MS）对三种洗脱单体（Bis-GMA、UDMA 和 TEGDMA）进行鉴定和定量。根据 ISO 4049 制备水吸附/溶解度试件。将来自每种固化模式（LC/SC）的试件分别浸入蒸馏水中 30d，然后在 37°C 下再处理 30d；试件的质量变化在不同的时间间隔进行测量。采用单因素方差分析、Tukey 事后检验和独立样本 t 检验（α=0.05）对数据进行分析。
结果
在 30d 的水储存后，水中检测到三种单体 Bis-GMA、UDMA 和 TEGDMA。所有单体均不同程度地洗脱到水中，与 LC 固化模式相比，SC 固化模式下的洗脱单体含量显著更高（p<0.0001）。BSE 具有最高的洗脱单体量。在 30d 的水吸附（μg/mm）后，除了 PV5、RXU 和 CEM（p>0.05）之外，所有再处理水门汀的 SC 固化模式的吸附量均显著高于 LC 固化模式（p<0.05）。在 30d 的水溶解度（μg/mm）后，所有树脂水门汀的 SC 固化模式的溶解度均显著高于 LC 固化模式（p<0.0001）。BSE 的水吸附和溶解度最高。洗脱单体的总量与溶解度呈正相关：LC 为 r=0.95，SC 为 r=0.93。
意义
只要能够进行光照，光固化仍然有利于减少树脂降解的程度和双固化树脂水门汀的相关性能。BSE 显示出统计学上最高的洗脱单体、吸附和溶解度程度。
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