Masters C J
Mech Ageing Dev. 1978 Jun;7(6):455-64. doi: 10.1016/0047-6374(78)90086-6.
The onotgenic characteristics of lactate dehydrogenase (LDH) isozymes in mammalian pre-implantation ova have been reviewed. Evidence has been provided that the ova of mice and other mammalian species contain enzyme activity in a masked form, and display turnover processes which possess distinctive characteristics by comparison with those in adult tissues. Also, the extraordinary high levels of LDH in the extracellular secretion of the mammaliam oviduct have been commented on, along with the influence of reproductive hormones on the activity and type of this enzyme. In addition, attention has been drawn to the unique characteristics of the oval micro-evironment, and the influence which such factors may exert on the realization of enzyme phenotype during early mammalian development.
乳酸脱氢酶（LDH）同工酶在哺乳动物植入前卵子中的致癌特性已被综述。已有证据表明，小鼠和其他哺乳动物的卵子含有以隐蔽形式存在的酶活性，并表现出与成年组织相比具有独特特征的周转过程。此外，还对哺乳动物输卵管细胞外分泌物中LDH的异常高水平以及生殖激素对该酶活性和类型的影响进行了评论。此外，人们还注意到卵子微环境的独特特征，以及这些因素在哺乳动物早期发育过程中对酶表型实现可能产生的影响。
