Vengalasetti Yasaswi V, Chertow Glenn M, Popat Rita
Department of Epidemiology and Population Health, Stanford University School of Medicine, Stanford, California.
Department of Epidemiology and Population Health, Stanford University School of Medicine, Stanford, California; Division of Nephrology, Department of Medicine, Stanford University School of Medicine, Stanford, California.
J Ren Nutr. 2022 Sep;32(5):537-541. doi: 10.1053/j.jrn.2021.11.003. Epub 2021 Nov 20.
Dysgeusia and dysosmia are known to be associated with end-stage renal disease. Whether dysgeusia and dysosmia are associated with nondialysis-requiring chronic kidney disease (CKD) is unknown.
We utilized data from the National Health and Nutrition Examination Survey during years 2011-14. We classified CKD by stage using standard criteria for the estimated glomerular filtration rate and the urine albumin-to-creatinine ratio. We used multivariable logistic regression analysis to determine the independent associations among CKD, CKD stage, and dysgeusia and dysosmia using a ChemoSensory Questionnaire.
After adjusting for the residual effects of age, sex, self-reported race, and diabetes, nondialysis-requiring CKD was significantly associated with dysgeusia ([odds ratio, 95% confidence interval] 1.34 [1.05, 1.70]); the association with dysosmia was of borderline significance, odds ratio 1.27 (0.97, 1.68). Odds of dysgeusia were higher at more severe CKD stages.
Nondialysis-requiring CKD is significantly associated with self-reported dysgeusia.
已知味觉障碍和嗅觉障碍与终末期肾病有关。味觉障碍和嗅觉障碍是否与无需透析的慢性肾脏病（CKD）有关尚不清楚。
我们利用了2011 - 14年美国国家健康和营养检查调查的数据。我们使用估计肾小球滤过率和尿白蛋白与肌酐比值的标准标准对CKD进行分期。我们使用多变量逻辑回归分析，通过化学感觉问卷来确定CKD、CKD分期与味觉障碍和嗅觉障碍之间的独立关联。
在调整了年龄、性别、自我报告的种族和糖尿病的残留影响后，无需透析的CKD与味觉障碍显著相关（[比值比，95%置信区间]1.34 [1.05, 1.70]）；与嗅觉障碍的关联具有临界显著性，比值比为1.27（0.97, 1.68）。在更严重的CKD阶段，味觉障碍的几率更高。
无需透析的CKD与自我报告的味觉障碍显著相关。
