Integrated single-cell sequencing and histopathological analyses reveal diverse injury and repair responses in a participant with acute kidney injury: a clinical-molecular-pathologic correlation.
作者信息
Menon Rajasree, Bomback Andrew S, Lake Blue B, Stutzke Christy, Grewenow Stephanie M, Menez Steven, D'Agati Vivette D, Jain Sanjay
机构信息
Department of Computational Medicine and Bioinformatics, University of Michigan, Ann Arbor, Michigan, USA.
Department of Medicine, Division of Nephrology, Columbia University, New York, New York, USA.
出版信息
Kidney Int. 2022 Jun;101(6):1116-1125. doi: 10.1016/j.kint.2022.03.011. Epub 2022 Mar 23.
Abstract
摘要
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Nature. 2023 Jul;619(7970):585-594. doi: 10.1038/s41586-023-05769-3. Epub 2023 Jul 19.
2
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Pharmaceuticals (Basel). 2010 Jul 21;3(7):2291-2321. doi: 10.3390/ph3072291.
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