Department of Neurosurgery, Oklahoma University Health Sciences Center, Oklahoma City, Oklahoma, USA.
Department of Neurosurgery, Oklahoma University Health Sciences Center, Oklahoma City, Oklahoma, USA.
World Neurosurg. 2022 Jun;162:e635-e639. doi: 10.1016/j.wneu.2022.03.088. Epub 2022 Mar 24.
Chondrosarcoma and chordoma are often grouped together because of their similar anatomic locations, clinical presentations, histopathological and radiological findings, and growth patterns. In the present study, we investigated the clinical and prognostic differences of chondrosarcomas and chordomas of the skull base and spine.
We accessed the Surveillance, Epidemiology, and End Results database to search for patients from 2000 to 2018 with chondrosarcomas and chordomas of the skull base and spine for inclusion in the present study.
We included 1346 and 1536 cases of chondrosarcoma and chordoma for analysis, respectively. Chondrosarcomas of the cranial base and spine were seen in younger patients and were associated with a larger tumor size compared with chordomas. Among the tumors of the skull base, chondrosarcomas were more common in women, with a male predominance found for chordomas. We also observed a male predilection for both spinal chondrosarcomas and chordomas. Distinct metastatic patterns were found for chondrosarcomas versus chordomas, and spinal chondrosarcomas showed a greater risk of distant metastases at presentation compared with spinal chordomas. Cranial base chondrosarcomas were associated with superior outcomes compared with chordomas. However, we demonstrated an opposite survival pattern for spinal chondrosarcomas and chordomas.
Chondrosarcomas and chordomas have divergent clinical manifestations and prognoses depending on the anatomic location.
软骨肉瘤和弦骨瘤常因解剖部位、临床表现、组织病理学和影像学表现以及生长方式相似而被归为一类。在本研究中，我们研究了颅底和脊柱的软骨肉瘤和 chordoma 的临床和预后差异。
我们访问了监测、流行病学和最终结果数据库，以搜索 2000 年至 2018 年期间患有颅底和脊柱软骨肉瘤和 chordoma 的患者，将其纳入本研究。
我们分别纳入了 1346 例和 1536 例软骨肉瘤和 chordoma 病例进行分析。颅底和脊柱的软骨肉瘤发生在较年轻的患者中，与 chordoma 相比，肿瘤体积较大。在颅底肿瘤中，软骨肉瘤多见于女性，而 chordoma 则多见于男性。我们还观察到，脊柱软骨肉瘤和 chordoma 均以男性为主。软骨肉瘤与 chordoma 的转移模式明显不同，与脊柱 chordoma 相比，脊柱软骨肉瘤在就诊时更易发生远处转移。颅底软骨肉瘤的预后优于 chordoma。然而，我们发现脊柱软骨肉瘤和 chordoma 的生存模式相反。
软骨肉瘤和弦骨瘤根据解剖部位表现出不同的临床表现和预后。
