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脊髓肿瘤的最新技术与新治疗方法

State-of-the-Art and New Treatment Approaches for Spinal Cord Tumors.

作者信息

Kumawat Chetan, Takahashi Toshiyuki, Date Isao, Tomita Yousuke, Tanaka Masato, Arataki Shinya, Komatsubara Tadashi, Flores Angel O P, Yu Dongwoo, Jain Mukul

机构信息

Department of Orthopedic Surgery, Okayama Rosai Hospital, 1-10-25 Chikkomidorimachi, Minami Ward Okayama, Okayama 702-8055, Japan.

Department of Orthopedic Surgery, Sir Ganga Ram Hospital, Rajinder Nagar, New Delhi 110060, India.

出版信息

Cancers (Basel). 2024 Jun 27;16(13):2360. doi: 10.3390/cancers16132360.

Abstract

Spinal cord tumors, though rare, present formidable challenges in clinical management due to their intricate nature. Traditional treatment modalities like surgery, radiation therapy, and chemotherapy have been the mainstay for managing these tumors. However, despite significant advancements, challenges persist, including the limitations of surgical resection and the potential side effects associated with radiation therapy. In response to these limitations, a wave of innovative approaches is reshaping the treatment landscape for spinal cord tumors. Advancements in gene therapy, immunotherapy, and targeted therapy are offering groundbreaking possibilities. Gene therapy holds the potential to modify the genes responsible for tumor growth, while immunotherapy harnesses the body's own immune system to fight cancer cells. Targeted therapy aims to strike a specific vulnerability within the tumor cells, offering a more precise and potentially less toxic approach. Additionally, novel surgical adjuncts are being explored to improve visualization and minimize damage to surrounding healthy tissue during tumor removal. These developments pave the way for a future of personalized medicine for spinal cord tumors. By delving deeper into the molecular makeup of individual tumors, doctors can tailor treatment strategies to target specific mutations and vulnerabilities. This personalized approach offers the potential for more effective interventions with fewer side effects, ultimately leading to improved patient outcomes and a better quality of life. This evolving landscape of spinal cord tumor management signifies the crucial integration of established and innovative strategies to create a brighter future for patients battling this complex condition.

摘要

脊髓肿瘤虽然罕见,但因其复杂的性质,在临床管理中面临着巨大挑战。手术、放射治疗和化疗等传统治疗方式一直是治疗这些肿瘤的主要手段。然而,尽管取得了重大进展,挑战依然存在,包括手术切除的局限性以及与放射治疗相关的潜在副作用。针对这些局限性,一波创新方法正在重塑脊髓肿瘤的治疗格局。基因治疗、免疫治疗和靶向治疗的进展提供了开创性的可能性。基因治疗有潜力改变导致肿瘤生长的基因,而免疫治疗则利用人体自身的免疫系统对抗癌细胞。靶向治疗旨在针对肿瘤细胞内的特定弱点,提供一种更精确且潜在毒性较小的方法。此外,正在探索新型手术辅助手段,以在肿瘤切除过程中改善可视化并将对周围健康组织的损伤降至最低。这些进展为脊髓肿瘤个性化医疗的未来铺平了道路。通过更深入地研究个体肿瘤的分子构成,医生可以制定针对特定突变和弱点的治疗策略。这种个性化方法有可能实现更有效的干预,副作用更少,最终改善患者的治疗效果和生活质量。脊髓肿瘤管理的这一不断演变的格局标志着既定策略与创新策略的关键整合,为与这种复杂疾病作斗争的患者创造更光明的未来。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5489/11240441/d78de7d084d6/cancers-16-02360-g001.jpg

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