School of medicine, University of Electronic Science and Technology of China, Chengdu 610072, Sichuan, China.
Key Laboratory of Solidification Control and Digital Preparation Technology (Liaoning Province), School of Materials Science and Engineering, Dalian University of Technology, Dalian, Liaoning, China, 116024.
Tissue Cell. 2022 Jun;76:101782. doi: 10.1016/j.tice.2022.101782. Epub 2022 Mar 9.
Corneal-related diseases and injuries are the leading causes of vision loss, estimated to affect over 10 million people worldwide. Currently, cadaveric corneal grafts are considered the gold standard of treatment to restore cornea-related vision. However, this treatment modality faces different challenges such as donor shortage and graft failure. Therefore, the need for alternative solutions continues to grow. Tissue engineering has dramatically progressed to produce artificial cornea implants in order to repair, regenerate, or replace the damaged cornea. In this regard, a variety of polysaccharides such as cellulose, chitosan, alginate, agarose, and hyaluronic acid have been widely explored as scaffolding biomaterials for the production of tissue-engineered cornea. These polymers are known for their excellent biocompatibility, versatile properties, and processability. Recent progress and future perspectives of polysaccharide-based biomaterials in cornea tissue engineering is reviewed here.
角膜相关疾病和损伤是导致视力丧失的主要原因，据估计，全球有超过 1000 万人受到影响。目前，尸体角膜移植被认为是恢复角膜相关视力的金标准治疗方法。然而，这种治疗方式面临着供体短缺和移植物失败等不同的挑战。因此，对替代解决方案的需求不断增长。组织工程学取得了显著进展，以生产人工角膜植入物，从而修复、再生或替代受损的角膜。在这方面，各种多糖如纤维素、壳聚糖、藻酸盐、琼脂糖和透明质酸已被广泛探索作为组织工程角膜的支架生物材料。这些聚合物以其优异的生物相容性、多功能性和可加工性而闻名。本文综述了基于多糖的生物材料在角膜组织工程中的最新进展和未来展望。
