Electrospun Polysaccharides for Periodontal Tissue Engineering: A Review of Recent Advances and Future Perspectives.

Periodontitis is the leading cause of tooth loss among the adult population. Indeed, conventional treatment modalities have specific challenges such as scar tissue infiltration, the formation of long epithelium junctions, and aesthetic limitations. Therefore, the development of alternative strategies is highly demanded. In this regard, periodontal tissue engineering has shed new light on the next generation of treatment methods. The essence of this technology is the use of appropriate biomaterials, bioactive agents, and fabrication technologies to mimic the natural extracellular matrix (ECM) of periodontal tissue. Among different candidates, the use of electrospun polysaccharides has gained significant attention. These structures possess a solid resemblance to native periodontal tissue's ECM in physicochemical, biological, and structural properties. The current review discusses the recent progress, challenges, and future perspectives of electrospun polysaccharides in periodontal tissue engineering.