Nanchang Central Hospital, The Second Clinical College of North Sichuan Medical College, Nanchong, 637000, China.
Department of Preventive Dentistry, College Stomatology, Xi'an Jiao Tong University, Xi'an, 710000, China.
Ann Biomed Eng. 2022 Jul;50(7):769-793. doi: 10.1007/s10439-022-02952-x. Epub 2022 Apr 15.
Periodontitis is the leading cause of tooth loss among the adult population. Indeed, conventional treatment modalities have specific challenges such as scar tissue infiltration, the formation of long epithelium junctions, and aesthetic limitations. Therefore, the development of alternative strategies is highly demanded. In this regard, periodontal tissue engineering has shed new light on the next generation of treatment methods. The essence of this technology is the use of appropriate biomaterials, bioactive agents, and fabrication technologies to mimic the natural extracellular matrix (ECM) of periodontal tissue. Among different candidates, the use of electrospun polysaccharides has gained significant attention. These structures possess a solid resemblance to native periodontal tissue's ECM in physicochemical, biological, and structural properties. The current review discusses the recent progress, challenges, and future perspectives of electrospun polysaccharides in periodontal tissue engineering.
牙周炎是成年人牙齿缺失的主要原因。事实上，传统的治疗方法存在一些特殊的挑战，如疤痕组织浸润、长上皮连接的形成以及美学限制。因此，人们迫切需要开发替代策略。在这方面，牙周组织工程为下一代治疗方法带来了新的希望。这项技术的本质是使用适当的生物材料、生物活性物质和制造技术来模拟牙周组织的天然细胞外基质 (ECM)。在不同的候选物中，使用静电纺丝多糖引起了广泛关注。这些结构在理化性质、生物学和结构特性方面与天然牙周组织的 ECM 具有高度相似性。本文综述了静电纺丝多糖在牙周组织工程中的最新进展、挑战和未来展望。
