基于生物大分子的尿道重建支架。

Biological Macromolecule-Based Scaffolds for Urethra Reconstruction.

机构信息

Centre de Recherche en Organogénèse Expérimentale/LOEX, Regenerative Medicine Division, CHU de Québec-Université Laval Research Center, Quebec, QC G1V 4G2, Canada.

Department of Tissue Engineering and Applied Cell Sciences, School of Advanced Technologies in Medicine, Shahid Beheshti University of Medical Sciences, Tehran 1983963113, Iran.

出版信息

Biomolecules. 2023 Jul 26;13(8):1167. doi: 10.3390/biom13081167.

DOI:10.3390/biom13081167

PMID:37627232

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10452429/

Abstract

Urethral reconstruction strategies are limited with many associated drawbacks. In this context, the main challenge is the unavailability of a suitable tissue that can endure urine exposure. However, most of the used tissues in clinical practices are non-specialized grafts that finally fail to prevent urine leakage. Tissue engineering has offered novel solutions to address this dilemma. In this technology, scaffolding biomaterials characteristics are of prime importance. Biological macromolecules are naturally derived polymers that have been extensively studied for various tissue engineering applications. This review discusses the recent advances, applications, and challenges of biological macromolecule-based scaffolds in urethral reconstruction.

摘要

尿道重建策略受到限制，且存在许多相关缺陷。在这种情况下，主要的挑战是缺乏能够耐受尿液暴露的合适组织。然而，在临床实践中使用的大多数组织都是非专用移植物，最终无法防止尿液泄漏。组织工程学为解决这一难题提供了新的解决方案。在这项技术中，支架生物材料的特性至关重要。生物大分子是天然来源的聚合物，已广泛研究用于各种组织工程应用。本文综述了生物大分子支架在尿道重建中的最新进展、应用和挑战。