School of Chemistry, The University of Edinburgh, West Mains Road, Kings Buildings, EH9 3JJ, UK.
Macromol Biosci. 2013 Apr;13(4):395-421. doi: 10.1002/mabi.201200409. Epub 2013 Mar 19.
Research and development in the design, synthesis, modification, evaluation, and characterization of polysaccharide-based bioactive polymeric materials for guiding and promoting new tissue in-growth is reviewed. Emphasis is given in this interdisciplinary field of tissue engineering (TE) with particular reference to bone, cartilage, and skin TE. Current strategies in scaffold-guided TE approaches using polymers of natural origin and their composites are elaborated. Innovative modification techniques in creating functional materials for advanced TE applications are presented. Challenges and possible solutions in the technological innovation in factor molecules incorporation and surface functionalization for improving the fabrication of biomaterials scaffolds for cost-effective TE are also presented.
本文综述了用于指导和促进新组织内生长的多糖基生物活性聚合材料的设计、合成、修饰、评价和特性研究与开发。重点介绍了组织工程（TE）这一跨学科领域，特别提到了骨、软骨和皮肤 TE。阐述了使用天然来源聚合物及其复合材料的支架引导 TE 方法的当前策略。介绍了用于先进 TE 应用的功能材料的创新修饰技术。还提出了在因子分子掺入和表面功能化方面进行技术创新以改进生物材料支架制造的挑战和可能的解决方案，以实现具有成本效益的 TE。
