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精-卵道相互作用：精子存活和维持精子受精能力的关键因素。

Sperm-oviduct interactions: Key factors for sperm survival and maintenance of sperm fertilizing capacity.

机构信息

School of Medicine, Health Sciences Centre, University College Dublin (UCD), Dublin, Ireland.

出版信息

Andrology. 2022 Jul;10(5):837-843. doi: 10.1111/andr.13179. Epub 2022 Apr 4.

DOI:10.1111/andr.13179
PMID:35340118
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9321146/
Abstract

BACKGROUND

Although millions or even billions of sperm are deposited in the female genital tract, only very few sperm reach the oocyte, and only one single spermatozoon will successfully fertilize. During the journey of the sperm within the female genital tract, the interactions between spermatozoa and fallopian tube are critical for sperm selection, sperm survival, and maintenance of sperm fertilizing capacity.

RESULTS

This review will provide a comprehensive overview of the latest findings regarding sperm transport and behavior of sperm within the oviduct, sperm selection in the oviduct, the formation of the sperm reservoir, and the release of sperm in the presence of the oocyte. It will primarily focus on recent novel insights on sperm-oviduct interactions, which have been obtained by cutting-edge technologies under in vivo or near in vivo conditions.

CONCLUSIONS

The comprehensive analysis of the findings to date will elucidate the complex molecular changes in the tubal epithelium, which are induced by the presence of the sperm and will highlight how the epithelial cells of this organ affect transport, behavior, and function of sperm. This knowledge is essential for scientists and clinicians involved in assisted reproductive technologies.

摘要

背景

尽管数以百万计甚至数十亿的精子被沉积在女性生殖道内，但只有极少数精子能够到达卵子，而且只有一个精子能够成功受精。在精子在女性生殖道内的旅程中，精子与输卵管之间的相互作用对于精子的选择、生存和保持受精能力至关重要。

结果

本文综述将全面概述最近关于精子在输卵管内的运输和行为、输卵管内的精子选择、精子库的形成以及在卵子存在下精子释放的最新发现。它将主要关注在体内或接近体内条件下通过尖端技术获得的关于精子-输卵管相互作用的新见解。

结论

对迄今为止的发现进行综合分析，将阐明由精子存在诱导的输卵管上皮的复杂分子变化，并强调该器官的上皮细胞如何影响精子的运输、行为和功能。这些知识对于从事辅助生殖技术的科学家和临床医生来说是必不可少的。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3b75/9321146/6216bfbe3d16/ANDR-10-837-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3b75/9321146/9f8612c64acb/ANDR-10-837-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3b75/9321146/0aefbface267/ANDR-10-837-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3b75/9321146/6216bfbe3d16/ANDR-10-837-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3b75/9321146/9f8612c64acb/ANDR-10-837-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3b75/9321146/0aefbface267/ANDR-10-837-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3b75/9321146/6216bfbe3d16/ANDR-10-837-g002.jpg

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