Clinical Laboratory, The Third Affiliated Hospital of Wenzhou Medical University, Wenzhou, China.
School of the First Clinical Medical Sciences, Wenzhou Medical University, Wenzhou, China.
Dis Markers. 2022 Mar 17;2022:1120192. doi: 10.1155/2022/1120192. eCollection 2022.
We aimed to evaluate and compare the association between globulin to albumin ratio (GAR) and globulin to prealbumin ratio (GPR) and 3-month functional prognosis of acute ischemic stroke (AIS) patients receiving intravenous thrombolysis therapy.
234 AIS patients undergoing intravenous thrombolysis were retrospectively enrolled with acute ischemic stroke from February 2016 to October 2019. Blood sample was collected within 24 h after admission. Poor outcome was defined as the modified Rankin Scale (mRS) ≥ 3 and a favorable outcome as mRS < 3. Severe stroke was defined as the National Institutes of Health Stroke Scale (NIHSS) score > 10 on admission. Student's -test, Mann-Whitney test, Chi-square test, logistics' regression analysis, and receiver operating characteristic (ROC) analysis were performed.
Patients with poor functional outcome had higher GAR and GPR levels compared with favorable functional group ( = 0.001, < 0.001, respectively). Severe stroke was also associated with these two increasing variables. After adjustment for confounding factors, multivariate logistic regression analysis indicated that GPR was an independent indicator predictor of AIS.
The 24 h GPR level can predict the 3-month functional outcome in AIS patients accepting recombinant tissue plasminogen activator (r-tPA) intravenous thrombosis.
我们旨在评估和比较球蛋白与白蛋白比值（GAR）和球蛋白与前白蛋白比值（GPR）与接受静脉溶栓治疗的急性缺血性脑卒中（AIS）患者 3 个月功能预后的相关性。
回顾性纳入 2016 年 2 月至 2019 年 10 月期间接受静脉溶栓的 234 例 AIS 患者。入院后 24 小时内采集血样。预后不良定义为改良 Rankin 量表（mRS）≥3，预后良好定义为 mRS<3。严重脑卒中定义为入院时国立卫生研究院脑卒中量表（NIHSS）评分>10。采用学生 t 检验、Mann-Whitney U 检验、卡方检验、逻辑回归分析和受试者工作特征（ROC）分析。
与功能良好组相比，预后不良组的 GAR 和 GPR 水平更高（=0.001，<0.001）。严重脑卒中也与这两个升高的变量相关。调整混杂因素后，多变量逻辑回归分析表明，GPR 是 AIS 的独立预测指标。
24 小时 GPR 水平可预测接受重组组织型纤溶酶原激活剂（r-tPA）静脉溶栓的 AIS 患者 3 个月的功能预后。
