Moote D W, Lloyd D A, McCourtie D R, Wells G A
J Allergy Clin Immunol. 1986 Oct;78(4 Pt 1):619-23. doi: 10.1016/0091-6749(86)90079-5.
There is an increased incidence in gastroesophageal reflux (GER) in subjects with asthma. The cause-effect relationship remains controversial. We compared 15 subjects with mild asthma to 15 control subjects (nonasthmatic) to ascertain if GER might be induced by bronchospasm. Continuous monitoring of lower esophageal sphincter pressure and pH at 5 cm above the lower esophageal sphincter was performed in seated subjects for 3 hours in total: 1 hour of baseline measurements, 1 hour of methacholine inhalation with a dosimeter, and 1 hour after the inhalation of 200 micrograms of salbutamol (albuterol). During bronchospasm, subjects with asthma had more episodes of GER (3.9 +/- 1.5) and dropped their pH to lower levels (pH 2.23 +/- 0.3) than did the control subjects (0.8 +/- 0.3 episodes, pH 3.22 +/- 0.3) p less than 0.05. We conclude that in these subjects with mild asthma, methacholine-induced bronchospasm produced GER episodes of greater frequency and severity.
哮喘患者胃食管反流（GER）的发病率有所增加。因果关系仍存在争议。我们将15名轻度哮喘患者与15名对照受试者（非哮喘患者）进行比较，以确定GER是否可能由支气管痉挛诱发。对坐位受试者的食管下括约肌压力和食管下括约肌上方5厘米处的pH值进行连续监测，共持续3小时：1小时基线测量，1小时用剂量仪吸入乙酰甲胆碱，以及吸入200微克沙丁胺醇（舒喘灵）后1小时。在支气管痉挛期间，哮喘患者发生GER的次数更多（3.9±1.5次），且pH值降至比对照受试者更低的水平（pH 2.23±0.3）（对照受试者为0.8±0.3次发作，pH 3.22±0.3），p<0.05。我们得出结论，在这些轻度哮喘患者中，乙酰甲胆碱诱发的支气管痉挛会导致GER发作的频率更高、程度更严重。
