Szefler S J
J Allergy Clin Immunol. 1986 Oct;78(4 Pt 2):710-5. doi: 10.1016/0091-6749(86)90050-3.
Sustained-release theophylline formulations are designed to provide consistent serum theophylline concentrations (STCs) by influencing the rate of theophylline absorption. The objective in developing these formulations is to minimize fluctuations in STC and improve patient compliance. Recent information, however, suggests that certain patients are susceptible to significant day-to-day and dose-to-dose variations in STC. The purpose of this discussion is to review information on conditions that affect theophylline absorption. These factors include the formulation, dosing interval, age of the patient, absence or presence of food, and gastrointestinal physiology. Appreciation of the potential variation in STC, secondary to inconsistencies in theophylline absorption, is important in the accurate interpretation of STC obtained during routine therapeutic monitoring.
缓释型茶碱制剂旨在通过影响茶碱的吸收速率来提供稳定的血清茶碱浓度（STC）。开发这些制剂的目的是将STC的波动降至最低并提高患者的依从性。然而，最近的信息表明，某些患者的STC存在显著的每日和剂量间差异。本讨论的目的是回顾影响茶碱吸收的相关情况的信息。这些因素包括制剂、给药间隔、患者年龄、有无食物以及胃肠生理状况。认识到由于茶碱吸收不一致导致的STC潜在变化，对于准确解读常规治疗监测期间获得的STC非常重要。
