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慢性复发性中性粒细胞性脑膜炎作为混合性结缔组织病患者诺卡菌病的唯一表现

Chronic relapsing neutrophilic meningitis as the sole manifestation of nocardiosis in a patient with mixed connective tissue disease.

作者信息

Albornoz M Anthony, Threlfall Erin K, Baldassari Michael Philip, Livornese Lawrence J

机构信息

Riddle Memorial Hospital/Main Line Health System, Dept. of Rheumatology, l̥1088 West Baltimore Pike Suite 2105, Health Center II, Media, PA 19063, USA.

Thomas Jefferson University, Dept. of Neurosurgery, 909 Walnut St #3, Philadelphia, PA 19107, USA.

出版信息

IDCases. 2022 Mar 9;28:e01473. doi: 10.1016/j.idcr.2022.e01473. eCollection 2022.

DOI:10.1016/j.idcr.2022.e01473
PMID:35340754
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC8941153/
Abstract

We describe a rare case of a patient with mixed connective tissue disease maintained on chronic oral corticosteroids, who was hospitalized on five occasions over five consecutive months due to persistent relapsing neutrophilic meningitis caused by . Immunosuppression due to the chronic use of corticosteroids was identified as the underlying mechanism of susceptibility. Our report highlights the challenges associated with systemic Nocardiosis, particularly in the immunocompromised host.

摘要

我们描述了一例患有混合性结缔组织病且长期口服皮质类固醇激素治疗的罕见病例,该患者在连续五个月内五次住院,病因是由……引起的持续性复发性嗜中性粒细胞性脑膜炎。长期使用皮质类固醇激素导致的免疫抑制被确定为易感性的潜在机制。我们的报告强调了系统性诺卡菌病相关的挑战,尤其是在免疫功能低下的宿主中。

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本文引用的文献

1
A case of central nervous system nocardiosis in a patient with lupus treated with belimumab.一例使用贝利尤单抗治疗的狼疮患者发生中枢神经系统诺卡菌病的病例。
Eur J Rheumatol. 2016 Dec;3(4):188-190. doi: 10.5152/eurjrheum.2016.15083. Epub 2016 Dec 1.
2
Nocardiosis of the central nervous system: experience from a general hospital and review of 84 cases from the literature.中枢神经系统诺卡菌病:一家综合医院的经验及对文献中84例病例的回顾
Medicine (Baltimore). 2014 Jan;93(1):19-32. doi: 10.1097/MD.0000000000000012.
3
Nocardiosis: updates and clinical overview.奴卡菌病:最新进展和临床概述。
Mayo Clin Proc. 2012 Apr;87(4):403-7. doi: 10.1016/j.mayocp.2011.11.016.
4
Persistent neutrophilic meningitis in an immunocompetent patient after basilar skull fracture: case report.免疫功能正常患者基底颅底骨折后持续性中性粒细胞性脑膜炎:病例报告。
BMC Infect Dis. 2011 May 19;11:136. doi: 10.1186/1471-2334-11-136.
5
Antimicrobial-resistant nocardia isolates, United States, 1995-2004.耐抗生素诺卡氏菌分离株,美国,1995-2004 年。
Clin Infect Dis. 2010 Dec 15;51(12):1445-8. doi: 10.1086/657399. Epub 2010 Nov 8.
6
Primary Nocardia meningitis in a patient without a predisposing condition: case report and review of the literature.无易感因素患者的原发性诺卡菌性脑膜炎:病例报告及文献复习
Scand J Infect Dis. 2007;39(8):737-41. doi: 10.1080/00365540701199873.
7
Clinical and laboratory features of the Nocardia spp. based on current molecular taxonomy.基于当前分子分类学的诺卡氏菌属的临床和实验室特征。
Clin Microbiol Rev. 2006 Apr;19(2):259-82. doi: 10.1128/CMR.19.2.259-282.2006.
8
A case series and focused review of nocardiosis: clinical and microbiologic aspects.诺卡菌病病例系列及重点综述:临床和微生物学方面
Medicine (Baltimore). 2004 Sep;83(5):300-313. doi: 10.1097/01.md.0000141100.30871.39.
9
Nocardia species: host-parasite relationships.诺卡氏菌属:宿主与寄生虫的关系。
Clin Microbiol Rev. 1994 Apr;7(2):213-64. doi: 10.1128/CMR.7.2.213.
10
Primary nocardial meningitis in systemic lupus erythematosus.系统性红斑狼疮中的原发性诺卡菌性脑膜炎。
Br J Rheumatol. 1995 Feb;34(2):178-81. doi: 10.1093/rheumatology/34.2.178.