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慢性复发性中性粒细胞性脑膜炎作为混合性结缔组织病患者诺卡菌病的唯一表现

Chronic relapsing neutrophilic meningitis as the sole manifestation of nocardiosis in a patient with mixed connective tissue disease.

作者信息

Albornoz M Anthony, Threlfall Erin K, Baldassari Michael Philip, Livornese Lawrence J

机构信息

Riddle Memorial Hospital/Main Line Health System, Dept. of Rheumatology, l̥1088 West Baltimore Pike Suite 2105, Health Center II, Media, PA 19063, USA.

Thomas Jefferson University, Dept. of Neurosurgery, 909 Walnut St #3, Philadelphia, PA 19107, USA.

出版信息

IDCases. 2022 Mar 9;28:e01473. doi: 10.1016/j.idcr.2022.e01473. eCollection 2022.

Abstract

We describe a rare case of a patient with mixed connective tissue disease maintained on chronic oral corticosteroids, who was hospitalized on five occasions over five consecutive months due to persistent relapsing neutrophilic meningitis caused by . Immunosuppression due to the chronic use of corticosteroids was identified as the underlying mechanism of susceptibility. Our report highlights the challenges associated with systemic Nocardiosis, particularly in the immunocompromised host.

摘要

我们描述了一例患有混合性结缔组织病且长期口服皮质类固醇激素治疗的罕见病例,该患者在连续五个月内五次住院,病因是由……引起的持续性复发性嗜中性粒细胞性脑膜炎。长期使用皮质类固醇激素导致的免疫抑制被确定为易感性的潜在机制。我们的报告强调了系统性诺卡菌病相关的挑战,尤其是在免疫功能低下的宿主中。

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本文引用的文献

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Nocardiosis: updates and clinical overview.奴卡菌病:最新进展和临床概述。
Mayo Clin Proc. 2012 Apr;87(4):403-7. doi: 10.1016/j.mayocp.2011.11.016.
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Nocardia species: host-parasite relationships.诺卡氏菌属:宿主与寄生虫的关系。
Clin Microbiol Rev. 1994 Apr;7(2):213-64. doi: 10.1128/CMR.7.2.213.

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