早期蛋白质能量营养不良影响 EEG 节律活动来源的终身发育轨迹。
Early protein energy malnutrition impacts life-long developmental trajectories of the sources of EEG rhythmic activity.
机构信息
The Clinical Hospital of Chengdu Brain Science Institute, MOE Key Lab for Neuroinformation, University of Electronic Science and Technology of China, Chengdu, China; McGill Center for Integrative Neuroscience Center MCIN. Ludmer Center for Mental Health. Montreal Neurological Institute, McGill University, Montreal, Canada.
The Clinical Hospital of Chengdu Brain Science Institute, MOE Key Lab for Neuroinformation, University of Electronic Science and Technology of China, Chengdu, China.
出版信息
Neuroimage. 2022 Jul 1;254:119144. doi: 10.1016/j.neuroimage.2022.119144. Epub 2022 Mar 24.
Protein Energy Malnutrition (PEM) has lifelong consequences on brain development and cognitive function. We studied the lifelong developmental trajectories of resting-state EEG source activity in 66 individuals with histories of Protein Energy Malnutrition (PEM) limited to the first year of life and in 83 matched classmate controls (CON) who are all participants of the 49 years longitudinal Barbados Nutrition Study (BNS). qEEGt source z-spectra measured deviation from normative values of EEG rhythmic activity sources at 5-11 years of age and 40 years later at 45-51 years of age. The PEM group showed qEEGt abnormalities in childhood, including a developmental delay in alpha rhythm maturation and an insufficient decrease in beta activity. These profiles may be correlated with accelerated cognitive decline.
蛋白质能量营养不良（PEM）会对大脑发育和认知功能产生终身影响。我们研究了 66 名一生中仅在生命的第一年经历过蛋白质能量营养不良（PEM）的个体以及 83 名匹配的同学对照组（CON）的静息状态脑电图源活动的终生发展轨迹，这些个体都是 49 年纵向巴巴多斯营养研究（BNS）的参与者。qEEGt 源 z-光谱测量了 5-11 岁和 40 年后 45-51 岁时 EEG 节律活动源的偏离正常值。PEM 组在儿童时期表现出 qEEGt 异常，包括 alpha 节律成熟的发育延迟和 beta 活动减少不足。这些特征可能与认知能力加速下降有关。
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