Linden E T, Abrams H, Matheny J, Kaplan A L, Kopczyk R A, Jasper S J
J Periodontol. 1986 Oct;57(10):637-42. doi: 10.1902/jop.1986.57.10.637.
This controlled, double-blind, split-mouth study was designed to evaluate postoperative pain experience following periodontal surgery on 20 patients. Two commercially available local anesthetic agents, bupivacaine HCl and lidocaine HCl, were used. Periodontal surgeries were standardized to minimize differences in difficulty, extent and time. A patient questionnaire was used to collect data for the 24-hour observation period following periodontal surgery. During this period, pain perception was assessed by visual analogue scales. The results indicated that when bupivacaine was used, there was less postoperative pain, fewer postoperative analgesics taken and a longer period of "numbness" (anesthesia) as compared to lidocaine. The patients expressed a strong preference for bupivacaine over lidocaine.
这项对照、双盲、分口研究旨在评估20例患者牙周手术后的疼痛体验。使用了两种市售局部麻醉剂，盐酸布比卡因和盐酸利多卡因。牙周手术进行了标准化，以尽量减少难度、范围和时间上的差异。使用患者问卷收集牙周手术后24小时观察期的数据。在此期间，通过视觉模拟量表评估疼痛感知。结果表明，与利多卡因相比，使用布比卡因时术后疼痛较轻，服用术后镇痛药较少，“麻木”（麻醉）时间较长。患者对布比卡因的偏好明显高于利多卡因。
