Rosenquist J B, Rosenquist K I, Lee P K
Anesth Prog. 1988 Jan-Feb;35(1):1-4.
The effect of lidocaine and bupivacaine on postoperative pain were compared in a double blind crossover study. Diflunisal (500 mg) was used as an analgesic and given before commencement of the surgical procedure.Bilateral impactions of lower third molars were removed on two occasions, four weeks apart, in a sample of 26 Chinese patients. One local anesthetic was used on one occasion and the alternate on the second. Pain intensity was indicated on a visual analogue scale hourly for eight hours, beginning one hour after the start of surgery.Pain at each postoperative hour was lower after bupivacaine and more patients indicated little or no pain after bupivacaine than after lidocaine. This was not reflected in patients' preference: 12 preferring lidocaine, 11 bupivacaine, and 3 indicating no preference, an important reason being a shorter period of numbness with lidocaine.Although diflunisal was given preoperatively, the postoperative course was not complicated by alveolitis in any case.While bupivacaine plus diflunisal resulted in less postoperative pain than lidocaine plus diflunisal, some patients were willing to sustain some pain after oral surgery if sensation was regained sooner.
在一项双盲交叉研究中,比较了利多卡因和布比卡因对术后疼痛的影响。双氟尼酸(500毫克)用作镇痛药,在手术开始前给药。在26名中国患者的样本中,分两次拔除双侧下颌第三磨牙阻生齿,每次间隔四周。一次使用一种局部麻醉剂,另一次使用另一种。从手术开始后一小时起,每小时用视觉模拟量表指示疼痛强度,持续八小时。布比卡因麻醉后,术后各小时的疼痛程度较低,与利多卡因相比,更多患者表示布比卡因麻醉后几乎没有疼痛。这在患者的偏好中并未体现出来:12人更喜欢利多卡因,11人更喜欢布比卡因,3人表示无偏好,一个重要原因是利多卡因导致的麻木时间较短。尽管术前给予了双氟尼酸,但在任何情况下术后病程均未因干槽症而复杂化。虽然布比卡因加双氟尼酸比利多卡因加双氟尼酸导致的术后疼痛更少,但如果能更快恢复感觉,一些患者愿意承受口腔手术后的一些疼痛。