文献检索文档翻译深度研究
Suppr Zotero 插件Zotero 插件
邀请有礼套餐&价格历史记录

新学期，新优惠

限时优惠:9月1日-9月22日

30天高级会员仅需29元

1天体验卡首发特惠仅需5.99元

了解详情
不再提醒
插件&应用
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
高级版
套餐订阅购买积分包
AI 工具
文献检索文档翻译深度研究
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2025

Analysis of Ferroptosis-Related LncRNAs Signatures Associated with Tumor Immune Infiltration and Experimental Validation in Clear Cell Renal Cell Carcinoma.

作者信息

Chen Xinyi, Tu Jingyao, Ma Li, Huang Yongbiao, Yang Chunguang, Yuan Xianglin

机构信息

Department of Oncology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, People's Republic of China.

Department of Urology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, People's Republic of China.

出版信息

Int J Gen Med. 2022 Mar 19;15:3215-3235. doi: 10.2147/IJGM.S354682. eCollection 2022.

DOI:10.2147/IJGM.S354682
PMID:35342303
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC8942346/
Abstract

BACKGROUND: Clear cell renal cell carcinoma (ccRCC) is the most aggressive subtype of renal cell carcinoma. Ferroptosis is an iron-dependent programmed cell death. Long non-coding RNAs (lncRNAs) emerge as a critical role in regulating cancer progression. OBJECTIVE: This study aimed to identify molecular regulation of ferroptosis-related lncRNAs (FRLs) in ccRCC. METHODS: The prognostic value of FRLs was investigated in ccRCC samples downloaded from The Cancer Genome Atlas (TCGA) and Gene Expression Omnibus (GEO) dataset. The FRLs were screened out by Pearson correlation test. The 465 FRLs confirmed as potential prognostic factors through univariate Cox regression analysis were entered into Lasso and multivariate Cox regression to build a FRLs prognostic signature. A risk score based on the prognostic model divided ccRCC patients into low- and high-risk groups. A prognostic nomogram, derived from the prognostic signature and integrating clinical characteristics, was constructed. Gene set enrichment analysis (GSEA) revealed the immune- and tumor-associated pathways. Two distinct clusters were identified with different immune signatures through consensus clustering analysis. The prognostic value of some hub FRLs was externally validated via three GEO datasets (GSE46699, GSE53757 and GSE66272) and online databases. Finally, the three FRLs (LINC00460, LINC00941 and LINC02027) were verified through in vitro experiments. RESULTS: The FRLs prognostic signature, including 7 independent prognostic lncRNAs, exhibited good accuracy in predicting overall survival (OS) of ccRCC patients. This signature was correlated with immune infiltration and immune checkpoint blockade (ICB). We correlated two distinct clusters with immune infiltration signature of ccRCC. The worse prognosis of cluster 2 was probably mediated by immune evasion. We also found that the expression levels of LINC00460 and LINC00941 in ccRCC cell lines were higher than those in HK-2 cells, but LINC02027 showed the inverse trend. CONCLUSION: Collectively, our study demonstrated a FRLs prognostic signature which had great clinical value in prognosis assessment.

摘要
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5448/8942346/81753aceb7fe/IJGM-15-3215-g0013.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5448/8942346/45f841055aee/IJGM-15-3215-g0001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5448/8942346/0535dcda7be4/IJGM-15-3215-g0002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5448/8942346/3a5b518114d0/IJGM-15-3215-g0003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5448/8942346/4c29e89a41ed/IJGM-15-3215-g0004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5448/8942346/86ff0dcd6808/IJGM-15-3215-g0005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5448/8942346/a2d3c495b225/IJGM-15-3215-g0006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5448/8942346/9afacfb67d28/IJGM-15-3215-g0007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5448/8942346/a7520b7ad7f9/IJGM-15-3215-g0008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5448/8942346/bc15e42dabfa/IJGM-15-3215-g0009.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5448/8942346/92499e1962e8/IJGM-15-3215-g0010.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5448/8942346/fa9a7fe05d16/IJGM-15-3215-g0011.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5448/8942346/4cce0d2f5e9e/IJGM-15-3215-g0012.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5448/8942346/81753aceb7fe/IJGM-15-3215-g0013.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5448/8942346/45f841055aee/IJGM-15-3215-g0001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5448/8942346/0535dcda7be4/IJGM-15-3215-g0002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5448/8942346/3a5b518114d0/IJGM-15-3215-g0003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5448/8942346/4c29e89a41ed/IJGM-15-3215-g0004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5448/8942346/86ff0dcd6808/IJGM-15-3215-g0005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5448/8942346/a2d3c495b225/IJGM-15-3215-g0006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5448/8942346/9afacfb67d28/IJGM-15-3215-g0007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5448/8942346/a7520b7ad7f9/IJGM-15-3215-g0008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5448/8942346/bc15e42dabfa/IJGM-15-3215-g0009.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5448/8942346/92499e1962e8/IJGM-15-3215-g0010.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5448/8942346/fa9a7fe05d16/IJGM-15-3215-g0011.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5448/8942346/4cce0d2f5e9e/IJGM-15-3215-g0012.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5448/8942346/81753aceb7fe/IJGM-15-3215-g0013.jpg

相似文献

[1]
Analysis of Ferroptosis-Related LncRNAs Signatures Associated with Tumor Immune Infiltration and Experimental Validation in Clear Cell Renal Cell Carcinoma.

Int J Gen Med. 2022-3-19

[2]
Construction of a ferroptosis-related signature based on seven lncRNAs for prognosis and immune landscape in clear cell renal cell carcinoma.

BMC Med Genomics. 2022-12-17

[3]
Construction of a ferroptosis-related five-lncRNA signature for predicting prognosis and immune response in thyroid carcinoma.

Cancer Cell Int. 2022-9-29

[4]
Identification and Validation of a Ferroptosis-Related Long Non-Coding RNA (FRlncRNA) Signature to Predict Survival Outcomes and the Immune Microenvironment in Patients With Clear Cell Renal Cell Carcinoma.

Front Genet. 2022-3-8

[5]
Ferroptosis-Related Long Noncoding RNA Signature Predicts Prognosis of Clear Cell Renal Carcinoma.

Folia Biol (Praha). 2022

[6]
Development and Validation of a Novel Ferroptosis-Related LncRNA Signature for Predicting Prognosis and the Immune Landscape Features in Uveal Melanoma.

Front Immunol. 2022

[7]
Comprehensive Analysis of N6-Methyladenosine-Related IncRNAs Prognostic Signature and the Associated Immune Infiltrates in Kidney Renal Clear Cell Carcinoma.

Crit Rev Eukaryot Gene Expr. 2022

[8]
A Prognostic Signature for Clear Cell Renal Cell Carcinoma Based on Ferroptosis-Related lncRNAs and Immune Checkpoints.

Front Genet. 2022-5-24

[9]
Computational construction of TME-related lncRNAs signature for predicting prognosis and immunotherapy response in clear cell renal cell carcinoma.

J Clin Lab Anal. 2022-8

[10]
Prediction of overall survival based upon a new ferroptosis-related gene signature in patients with clear cell renal cell carcinoma.

World J Surg Oncol. 2022-4-14

引用本文的文献

[1]
Ferroptosis-related lncRNAs as prognostic biomarkers in renal cell carcinoma: a systematic review and meta-analysis.

Front Oncol. 2025-5-23

[2]
Identification of ferroptosis-related gene signatures as a novel prognostic model for clear cell renal cell carcinoma.

Discov Oncol. 2025-4-3

[3]
Integrated bioinformatics and validation reveal SOX12 as potential biomarker in colon adenocarcinoma based on an immune infiltration-related ceRNA network.

J Cancer Res Clin Oncol. 2023-11

[4]
Identification and in vitro and in vivo validation of the key role of GSDME in pyroptosis-related genes signature in hepatocellular carcinoma.

BMC Cancer. 2023-5-6

[5]
A novel oxidative-stress related lncRNA signature predicts the prognosis of clear cell renal cell carcinoma.

Sci Rep. 2023-4-7

[6]
Regulatory roles of ferroptosis-related non-coding RNAs and their research progress in urological malignancies.

Front Genet. 2023-3-2

[7]
Identification and validation of a ferroptosis-related lncRNA signature to robustly predict the prognosis, immune microenvironment, and immunotherapy efficiency in patients with clear cell renal cell carcinoma.

PeerJ. 2022

[8]
Identification and Validation of a Novel Ferroptotic Prognostic Genes-Based Signature of Clear Cell Renal Cell Carcinoma.

Cancers (Basel). 2022-9-27

[9]
MiRNA-148a inhibits cell growth and drug resistance by regulating expression in renal cell carcinoma.

Transl Androl Urol. 2022-7

[10]
Cuproptosis-Associated lncRNA Establishes New Prognostic Profile and Predicts Immunotherapy Response in Clear Cell Renal Cell Carcinoma.

Front Genet. 2022-7-15

本文引用的文献

[1]
Development and validation of ferroptosis-related lncRNAs signature for hepatocellular carcinoma.

PeerJ. 2021-6-11

[2]
HIF-2α activation potentiates oxidative cell death in colorectal cancers by increasing cellular iron.

J Clin Invest. 2021-6-15

[3]
LINC00460 Is a Dual Biomarker That Acts as a Predictor for Increased Prognosis in Basal-Like Breast Cancer and Potentially Regulates Immunogenic and Differentiation-Related Genes.

Front Oncol. 2021-4-12

[4]
Smart biomimetic metal organic frameworks based on ROS-ferroptosis-glycolysis regulation for enhanced tumor chemo-immunotherapy.

J Control Release. 2021-6-10

[5]
Ferroptosis-Related Long Non-Coding RNA signature predicts the prognosis of Head and neck squamous cell carcinoma.

Int J Biol Sci. 2021

[6]
Development and validation of a ferroptosis-related lncRNAs prognosis signature in colon cancer.

Bosn J Basic Med Sci. 2021-10-1

[7]
Release mechanisms of major DAMPs.

Apoptosis. 2021-4

[8]
Long noncoding RNA LINC00941 promotes pancreatic cancer progression by competitively binding miR-335-5p to regulate ROCK1-mediated LIMK1/Cofilin-1 signaling.

Cell Death Dis. 2021-1-4

[9]
Vaccination with early ferroptotic cancer cells induces efficient antitumor immunity.

J Immunother Cancer. 2020-11

[10]
Artesunate Inhibits Growth of Sunitinib-Resistant Renal Cell Carcinoma Cells through Cell Cycle Arrest and Induction of Ferroptosis.

Cancers (Basel). 2020-10-27

文献AI研究员

20分钟写一篇综述，助力文献阅读效率提升50倍

立即体验

用中文搜PubMed

大模型驱动的PubMed中文搜索引擎

马上搜索

推荐工具

医学文档翻译智能文献检索