Wang Shijin, Jiang Bowen, Xie Deqian, Li Xiunan, Wu Guangzhen
Department of Urology, The First Affiliated Hospital of Dalian Medical University, Dalian, China.
Front Genet. 2023 Mar 2;14:1133020. doi: 10.3389/fgene.2023.1133020. eCollection 2023.
Ferroptosis is a new type of cell death characterized by damage to the intracellular microenvironment, which causes the accumulation of lipid hydroperoxide and reactive oxygen species to cause cytotoxicity and regulated cell death. Non-coding RNAs (ncRNAs) play an important role in gene expression at the epigenetic, transcriptional, and post-transcriptional levels through interactions with different DNAs, RNAs, or proteins. Increasing evidence has shown that ferroptosis-related ncRNAs are closely related to the occurrence and progression of several diseases, including urological malignancies. Recently, the role of ferroptosis-associated ncRNAs (long non-coding RNAs, micro RNAs, and circular RNAs) in the occurrence, drug resistance, and prognosis of urological malignancies has attracted widespread attention. However, this has not yet been addressed systematically. In this review, we discuss this issue as much as possible to expand the knowledge and understanding of urological malignancies to provide new ideas for exploring the diagnosis and treatment of urological malignancies in the future. Furthermore, we propose some challenges in the clinical application of ferroptosis-associated ncRNAs.
铁死亡是一种新型细胞死亡方式，其特征是细胞内微环境受损，导致脂质氢过氧化物和活性氧积累，进而引起细胞毒性和程序性细胞死亡。非编码RNA（ncRNA）通过与不同的DNA、RNA或蛋白质相互作用，在表观遗传、转录和转录后水平的基因表达中发挥重要作用。越来越多的证据表明，与铁死亡相关的ncRNA与包括泌尿系统恶性肿瘤在内的多种疾病的发生和进展密切相关。最近，铁死亡相关的ncRNA（长链非编码RNA、微小RNA和环状RNA）在泌尿系统恶性肿瘤的发生、耐药性和预后中的作用引起了广泛关注。然而，这一问题尚未得到系统阐述。在本综述中，我们尽可能多地讨论这一问题，以扩展对泌尿系统恶性肿瘤的认识和理解，为未来探索泌尿系统恶性肿瘤的诊断和治疗提供新思路。此外，我们还提出了铁死亡相关ncRNA在临床应用中的一些挑战。
