Emergency Department, Patan Hospital, Lalitpur, Nepal.
Department of Internal Medicine, Union Memorial Hospital, Baltimore, MD, USA.
F1000Res. 2021 Aug 2;10:723. doi: 10.12688/f1000research.55187.1. eCollection 2021.
Sarcomatoid carcinoma of the lung is an uncommon subtype of non-small-cell lung cancer (NSCLC). Even in the early stages, pulmonary sarcomatoid carcinoma (PSC) has a dismal prognosis when compared to other kinds of NSCLC with a mean survival of 9-12 months and a five-year survival rate of around 20%. We present the case of a 68-year-old woman with a two-month history of shortness of breath and cough. Initial computed tomography (CT) scan showed features of interstitial lung disease with chronic obstructive airway changes. After 34 months, the patient's condition worsened with newer complaints of sore throat and hemoptysis. A repeat CT scan showed a ∼49x38x59mm size lesion in the superior segment of the left lower lobe. A core needle biopsy was performed, which revealed tumor cells consisting of irregular tubules and sarcomatoid components. The patient was started on chemotherapy. Unfortunately, she succumbed to her disease. Our case highlights the aggressiveness of PSC.
肺肉瘤样癌是一种非小细胞肺癌（NSCLC）的罕见亚型。与其他类型的 NSCLC 相比，即使在早期阶段，肺肉瘤样癌（PSC）的预后也非常差，平均生存期为 9-12 个月，五年生存率约为 20%。我们报告了一例 68 岁女性患者，有两个月的呼吸困难和咳嗽病史。初始计算机断层扫描（CT）显示间质性肺疾病特征，伴有慢性阻塞性气道改变。34 个月后，患者病情恶化，出现新的咽痛和咯血症状。重复 CT 扫描显示左肺下叶上段有一个大小约为 49x38x59mm 的病变。进行了芯针活检，显示肿瘤细胞由不规则的小管和肉瘤样成分组成。患者开始接受化疗。不幸的是，她最终还是死于该病。我们的病例强调了 PSC 的侵袭性。
