Agarwal Anushka, Rao Gyaneshwar K, Majumder Sudip, Shandilya Manish, Rawat Varun, Purwar Roli, Verma Monu, Srivastava Chandra Mohan
Department of Chemistry, Biochemistry and Forensic Science, Amity School of Applied Sciences, Amity University Haryana, Gurugram, 122413 India.
Department of Applied Chemistry, Delhi Technological University, New Delhi, Delhi 110042 India.
3 Biotech. 2022 Apr;12(4):92. doi: 10.1007/s13205-022-03152-z. Epub 2022 Mar 14.
Electrospinning is an electrostatic fiber fabrication technique that operates by the application of a strong electric field on polymer solution or melts. It is used to fabricate fibers whose size lies in the range of few microns to the nanometer range. Historic development of electrospinning has evinced attention due to its outstanding attributes such as small diameter, excellent pore inter-connectivity, high porosity, and high surface-to-volume ratio. This review aims to highlight the theory behind electrospinning and the machine setup with a detailed discussion about the processing parameters. It discusses the latest innovations in natural protein-based electrospun nanofibers for health care applications. Various plant- and animal-based proteins have been discussed with detailed sample preparation and corresponding processing parameters. The usage of these electrospun nanofibers in regenerative medicine and drug delivery has also been discussed. Some technical innovations in electrospinning techniques such as emulsion electrospinning and coaxial electrospinning have been highlighted. Coaxial electrospun core-shell nanofibers have the potential to be utilized as an advanced nano-architecture for sustained release targeted delivery as well as for regenerative medicine. Healthcare applications of nanofibers formed via emulsion and coaxial electrospinning have been discussed briefly. Electrospun nanofibers have still much scope for commercialization on large scale. Some of the available wound-dressing materials have been discussed in brief.
静电纺丝是一种静电纤维制造技术，通过对聚合物溶液或熔体施加强电场来运作。它用于制造尺寸在几微米到纳米范围内的纤维。静电纺丝的历史发展因其突出特性，如小直径、优异的孔隙互连性、高孔隙率和高比表面积，而备受关注。本综述旨在突出静电纺丝背后的理论以及机器设置，并详细讨论加工参数。它探讨了用于医疗保健应用的天然蛋白质基静电纺纳米纤维的最新创新。已讨论了各种基于植物和动物的蛋白质，并给出了详细的样品制备方法和相应的加工参数。还讨论了这些静电纺纳米纤维在再生医学和药物递送中的应用。突出了静电纺丝技术中的一些技术创新，如乳液静电纺丝和同轴静电纺丝。同轴静电纺核壳纳米纤维有潜力用作先进的纳米结构，用于缓释靶向递送以及再生医学。简要讨论了通过乳液和同轴静电纺丝形成的纳米纤维在医疗保健方面的应用。静电纺纳米纤维在大规模商业化方面仍有很大空间。简要讨论了一些现有的伤口敷料材料。
