Büttner-Herold Maike, Gaspert Ariana, Amann Kerstin
Abteilung Nephropathologie, Pathologisches Institut, Universitätsklinikum Erlangen, Krankenhausstr. 8-10, 91054, Erlangen, Deutschland.
Abt. Nephropathologie, Institut für Pathologie und Molekularpathologie, Universitätsspital Zürich, Schmelzbergstr. 12, 8091, Zürich, Schweiz.
Pathologe. 2022 May;43(3):231-246. doi: 10.1007/s00292-022-01061-9. Epub 2022 Mar 28.
The assessment of kidney biopsies is mainly confined to specialized centres. However, sometimes a kidney biopsy is submitted to a general pathologist, and in addition peritumorous renal parenchyma in tumour nephrectomies can have concomitant non-neoplastic renal disease. Here we present a survey of inflammatory and immunologic changes in all renal compartments, which may in part indicate the need of prompt therapeutic intervention such as in vasculitis, glomerulonephritis and interstitial nephritis. It is important to take into account that renal involvement of vasculitis is mainly centred in glomeruli and only to a much lesser extent in arteries, and that the frequently observed interstitial inflammation very often is an epiphenomenon of another primary kidney disease and not an independent disease process. Typical renal patterns of injury are emphasised.
肾活检的评估主要局限于专业中心。然而，有时肾活检标本会送交普通病理学家，此外，肿瘤肾切除术中肿瘤周围的肾实质可能伴有非肿瘤性肾脏疾病。在此，我们展示了对所有肾组织中炎症和免疫变化的调查，这些变化在一定程度上可能表明需要及时进行治疗干预，如血管炎、肾小球肾炎和间质性肾炎。需要注意的是，血管炎累及肾脏主要集中在肾小球，而在动脉中的累及程度要小得多，并且经常观察到的间质炎症往往是另一种原发性肾脏疾病的附带现象，而非独立的疾病过程。文中强调了典型的肾脏损伤模式。
