C-亚硝硫醚：同时释放 HNO 和 H2S 的供体模板。
C-Nitrosothioformamide: A Donor Template for Dual Release of HNO and H S.
机构信息
Department of Chemistry, Washington State University, Pullman, WA 99164, USA.
Department of Chemistry, Brown University, Providence, RI 02912, USA.
出版信息
Chembiochem. 2022 Jul 5;23(13):e202200101. doi: 10.1002/cbic.202200101. Epub 2022 Apr 7.
Abstract
C-Nitrosothioformamide was demonstrated to be a donor template for dual release of HNO and COS triggered by a retro-Diels-Alder reaction. COS is an H S precursor in the presence of carbonic anhydrase. This process produces HNO and H S in a slow but steady manner. As such, the direct reaction between HNO and H S under this situation appears to be minor. This may provide a useful tool for studying the synergistic effects of HNO and H S.
摘要
C-亚硝硫代酰胺被证明是一种供体模板，可通过反-Diels-Alder 反应引发 HNO 和 COS 的双重释放。COS 是碳酸酐酶存在时的 H 2 S 前体。该过程以缓慢但稳定的方式产生 HNO 和 H 2 S。因此，在此情况下，HNO 和 H 2 S 之间的直接反应似乎不太重要。这可能为研究 HNO 和 H 2 S 的协同作用提供了有用的工具。
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