Key Laboratory of Fermentation Engineering (Ministry of Education), National "111" Center for Cellular Regulation and Molecular Pharmaceutics, Hubei Key Laboratory of Industrial Microbiology, Hubei Research Center of Food Fermentation Engineering and Technology, Hubei University of Technology, Wuhan 430068, China.
The Second Affiliated Hospital of Dalian Medical University, Dalian 116027, China.
Aging (Albany NY). 2022 Mar 28;14(6):2880-2901. doi: 10.18632/aging.203981.
Although complex links between heterogeneous nuclear ribonucleoprotein C (HNRNPC) and numerous types of cancer have been shown in both cell and animal models, a comprehensive pan-cancer investigation on the features and activities of HNRNPC is still lacking. Based on the Cancer Genome Atlas and Gene Expression Omnibus datasets, we investigated the possible oncogenic effects of HNRNPC in thirty-three cancers. HNRNPC expression was detected in the majority of cancers, and its expression level was shown to be significantly linked with cancer patient prognosis. HNRNPC increased the phosphorylation of S220, which was detected in various cancers, including ovarian cancer and colon cancer. HNRNPC expression was also shown to be related to cancer-associated cell infiltration, most notably in uveal melanoma, testicular germ cell tumors, and thymoma. Additionally, the signaling pathway for vascular endothelial growth factors and RNA transport were implicated in HNRNPC's functioning processes. In short, HNRNPC may further influence cancer progression through gene mutation, protein phosphorylation, cancer associated fibroblasts infiltration and related molecular pathways. This work was intended to provide a relatively thorough knowledge of the oncogenic activities of HNRNPC across a variety of tumor types by performing a systematic pan-cancer investigation.
尽管在细胞和动物模型中已经证明了异质核核糖核蛋白 C（HNRNPC）与多种类型的癌症之间存在复杂的联系，但对 HNRNPC 在所有癌症中的特征和活性进行全面的泛癌症研究仍然缺乏。基于癌症基因组图谱和基因表达综合数据集，我们研究了 HNRNPC 在 33 种癌症中的潜在致癌作用。HNRNPC 在大多数癌症中均有表达，并且其表达水平与癌症患者的预后显著相关。HNRNPC 增加了 S220 的磷酸化，这在包括卵巢癌和结肠癌在内的多种癌症中均有检测到。HNRNPC 的表达也与癌症相关的细胞浸润有关，在葡萄膜黑色素瘤、睾丸生殖细胞肿瘤和胸腺瘤中最为明显。此外，血管内皮生长因子和 RNA 转运的信号通路也与 HNRNPC 的功能过程有关。总之，HNRNPC 可能通过基因突变、蛋白质磷酸化、癌症相关成纤维细胞浸润以及相关分子途径进一步影响癌症的进展。这项工作旨在通过进行系统的泛癌症研究，为 HNRNPC 在多种肿瘤类型中的致癌活性提供相对全面的认识。
