Machino Masaaki, Nakashima Hiroaki, Ito Keigo, Ando Kei, Ito Sadayuki, Kato Fumihiko, Imagama Shiro
Department of Orthopedic Surgery, Nagoya University Graduate School of Medicine, 65 Tsurumai, Showa-ku, Nagoya, Aichi 466-8550, Japan.
Department of Orthopedic Surgery, Nagoya University Graduate School of Medicine, 65 Tsurumai, Showa-ku, Nagoya, Aichi 466-8550, Japan.
J Clin Neurosci. 2022 May;99:342-348. doi: 10.1016/j.jocn.2022.03.035. Epub 2022 Mar 25.
The aim of this study was to establish the age-related changes and gender-specific differences of cervical disc degeneration using magnetic resonance image (MRI) and to evaluate the correlation between the severity of cervical disc degeneration and mobility in asymptomatic subjects. A total of 1,211 relatively healthy volunteers (606 males and 605 females, mean age 49.5 years) without neurological symptoms underwent MRI. At least 100 males and 100 females in each decade of life between the 20 s and the 70 s were included. This study was part of a larger project and used some previously published data. Cervical disc degeneration was defined according to the modified Pfirrmann classification system. A total disc degeneration score (DDS) was calculated by the summation of individual Pfirrmann scores from C2/C3 to C7/T1. Cervical range of motion (ROM) was measured by radiograph. The total DDS increased gradually with increasing age in both genders. DDSs were lower in females than in males in all decades. A DDS of 13 or more was found in more than half the cases in the 40 s or older age groups. The total DDS was 13 or more in over 95% of the cases in the 70 s age group. The total DDS was significantly and negatively correlated with cervical ROM overall (r = - 0.46, p < 0.0001) and in both men (r = - 0.52, p < 0.0001) and women (r = - 0.40, p < 0.0001). This large-scale cross-sectional analysis of cervical spine MRI data in healthy subjects demonstrated that cervical disc degeneration progresses with age, and is correlated with a reduction in mobility.
本研究旨在利用磁共振成像（MRI）确定颈椎间盘退变的年龄相关变化和性别差异，并评估无症状受试者颈椎间盘退变严重程度与活动度之间的相关性。共有1211名相对健康、无神经症状的志愿者（606名男性和605名女性，平均年龄49.5岁）接受了MRI检查。纳入了20多岁至70多岁每个十年中至少100名男性和100名女性。本研究是一个更大项目的一部分，并使用了一些先前发表的数据。颈椎间盘退变根据改良的Pfirrmann分类系统进行定义。通过将C2/C3至C7/T1的个体Pfirrmann评分相加计算出椎间盘退变总分（DDS）。颈椎活动范围（ROM）通过X线片测量。男女两性的DDS总分均随年龄增长而逐渐增加。在所有十年中，女性的DDS均低于男性。在40岁及以上年龄组中，超过一半的病例DDS为13或更高。在70岁年龄组中，超过95%的病例DDS为13或更高。DDS总分与颈椎ROM总体呈显著负相关（r = -0.46，p < 0.0001），在男性（r = -0.52，p < 0.0001）和女性（r = -0.40，p < 0.0001）中均如此。这项对健康受试者颈椎MRI数据的大规模横断面分析表明，颈椎间盘退变随年龄进展，且与活动度降低相关。
