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超重和肥胖个体颈椎病手术后的体重变化模式:一项全国性纵向研究。

Weight change patterns following surgery for cervical spondylosis in overweight and obese individuals: a nationwide longitudinal study.

作者信息

El-Hajj Victor Gabriel, Gustafsson Marcus Roland Victor, Clement Blake, Staartjes Victor E, Bydon Mohamad, Gerdhem Paul, Elmi-Terander Adrian, Edström Erik

机构信息

Department of Clinical Neuroscience, Karolinska Institutet, Stockholm, Sweden.

Machine Intelligence in Clinical Neuroscience & Microsurgical Neuroanatomy (MICN) Laboratory, Department of Neurosurgery, Clinical Neuroscience Center, University Hospital Zurich, University of Zurich, Zurich, Switzerland.

出版信息

Eur Spine J. 2025 Jun 18. doi: 10.1007/s00586-025-09070-x.

Abstract

INTRODUCTION

Cervical spondylosis may cause pain and disability, which leads to reduced activity levels and subsequent weight gains in affected patients. Surgical treatment of cervical spondylosis has been shown to improve quality of life and restore physical activity levels.

OBJECTIVE

We hence hypothesized that surgery in obese and overweight patients may lead to significant weight loss by means of pain and disability reduction as well as restoration of physical activity. This study aims to investigate whether surgery for cervical spondylosis leads to postoperative weight changes in overweight and obese patients.

METHODS

This is a retrospective longitudinal cohort study using prospective data. Obese and overweight patients who underwent surgery for cervical spondylosis in Sweden from 2005 to 2020, using the Swedish National Spine Register (SweSpine). Weight and BMI at both 1- and 2-years postoperatively were included in the analysis. Significant postoperative weight loss was considered as a loss of ≥ 5% of the initial preoperative weight and was the primary outcome of the study.

RESULTS

Of the 4,231 patients included in the main analysis, 32% were obese and 68% overweight. At 1-year follow-up, 25% of obese and 15% of overweight patients showed significant weight loss (≥ 5%, average 7 kg), increasing to 28% and 19% respectively by 2 years (p < 0.001). Younger patients (< 60 years) were more likely to lose significant weight at 1 year compared to older patients (20% vs. 16%, p = 0.005). Predictors of significant weight loss included obesity (OR: 1.87), NDI (OR: 1.01), NRS arm pain score (OR: 1.03), and NRS neck pain score (OR: 1.03), while male sex was linked to a lower likelihood of weight loss (OR: 0.74).

DISCUSSION

In conclusion, this study indicates that cervical spondylosis surgery may be associated with significant weight loss, particularly in younger and obese patients. Other predictors included higher preoperative pain and disability levels and female sex. Nonetheless, significant weight loss only occurred in a minority of patients. Future research should investigate the impact of a multidisciplinary approach on weight management and further examine additional predictive factors influencing weight loss.

摘要

引言

颈椎病可能导致疼痛和功能障碍,进而使患者活动水平降低,体重增加。已证实,颈椎病的手术治疗可改善生活质量并恢复身体活动水平。

目的

因此,我们推测,肥胖和超重患者接受手术可能会因疼痛和功能障碍减轻以及身体活动恢复而显著减重。本研究旨在调查颈椎病手术是否会导致超重和肥胖患者术后体重变化。

方法

这是一项使用前瞻性数据的回顾性纵向队列研究。利用瑞典国家脊柱登记册(SweSpine),对2005年至2020年在瑞典接受颈椎病手术的肥胖和超重患者进行研究。分析纳入术后1年和2年时的体重和体重指数。术后显著减重定义为初始术前体重减轻≥5%,这是本研究的主要结局。

结果

在纳入主要分析的4231例患者中,32%为肥胖患者,68%为超重患者。在1年随访时,25%的肥胖患者和15%的超重患者出现显著减重(≥5%,平均减重7千克),到2年时分别增至28%和19%(p<0.001)。与老年患者相比,年轻患者(<60岁)在1年时更有可能显著减重(20%比16%,p=0.005)。显著减重的预测因素包括肥胖(比值比:1.87)、颈痛指数(NDI,比值比:1.01)、上肢疼痛数字评定量表(NRS)评分(比值比:1.03)和颈部疼痛NRS评分(比值比:1.03),而男性体重减轻的可能性较低(比值比:0.74)。

讨论

总之,本研究表明,颈椎病手术可能与显著减重有关,尤其是在年轻和肥胖患者中。其他预测因素包括术前较高的疼痛和功能障碍水平以及女性性别。尽管如此,只有少数患者出现显著减重。未来的研究应调查多学科方法对体重管理的影响,并进一步研究影响体重减轻的其他预测因素。

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