Department of Orthopedic Surgery, West China Hospital, Sichuan University, Chengdu, China.
Department of Orthopedics, People's Hospital of Ningxia Hui Autonomous Region, Ningxia, China.
Front Endocrinol (Lausanne). 2024 Jun 19;15:1391970. doi: 10.3389/fendo.2024.1391970. eCollection 2024.
To investigate the relationship between degeneration of cervical intervertebral disc and degeneration of paravertebral muscles[multifidus (MF), cervical semispinalis (SCer), semispinalis capitis (SCap) and splenius capitis (SPL)].
82 patients with chronic neck pain were randomly selected, including 43 males and 39 females, with 50.73 0.7.51 years old. All patients were scanned by 3.0T MRI Philips Ingenia performed conventional MRI sequence scanning and fat measurement sequence mDIXON-Quant scanning of cervical. Fat infiltration (FI) and cross-sectional area (CSA) of cervical paravertebral muscle (MF, SCer, SCap and SPL) at central level of C5-6 disc were measured by Philips 3.0T MRI image post-processing workstation. According to Pfirrmann grading system, there was no grade I in the included cases. The number of grade IIr IV cases were n=16, 40, 19 and 7 respectively. CSA and FI of cervical paravertebral muscles were compared with t test or one-way ANOVA, Spearman correlation analysis was used to evaluate the correlation between age, disc degeneration, and CSA, FI of cervical paravertebral muscles, and multiple linear regression analysis was used to analyze the independent influencing factors of CSA and FI.
CSA of cervical paravertebral muscles in male patients was significantly higher than that in female patients (all P<0.001), but there was no significant difference in FI (all P>0.05). Age was weakly correlated with CSA of MF+SCer, moderately correlated with CSA of SCap and SPL (r=-0.256, -0.355 and -0.361, P<0.05), weakly correlated with FI of SCap and SPL (r= 0.182 and 0.264, P<0.001), moderately correlated with FI of MF+SCer (r=0.408, P<0.001). There were significant differences in FI with disc degeneration (P<0.001, P=0.028 and P=0.005). Further correlation analysis showed that disc degeneration was strongly correlated with FI of MF+SCer (r=0.629, P<0.001), and moderately correlated with FI of SCap and SPL (r=0.363, P=0.001; r=0.345, P=0.002). Multiple linear regression analysis showed that sex and age were the influencing factors of CSA of SCap and SPL, sex was the independent influencing factor of CSA of MF+SCer, and disc degeneration was the independent influencing factor of FI.
Age is negatively correlated with CSA and positively correlated with FI. Disc degeneration was correlated with FI of paravertebral muscles, especially with FI of MF and SCer. Sex and age were the influencing factors of CSA, while disc degeneration was the independent influencing factor of FI.
探讨颈椎间盘退变与椎旁肌（多裂肌[MF]、颈半棘肌[SCer]、头夹肌[SCap]和头最长肌[SPL]）退变的关系。
随机选择 82 例慢性颈痛患者，男 43 例，女 39 例，年龄 50.73±0.75 岁。所有患者均采用飞利浦 Ingenia 3.0T MRI 行常规 MRI 序列扫描和脂肪测量序列 mDIXON-Quant 扫描颈椎。在 C5-6 椎间盘中央水平测量颈椎旁肌（MF、SCer、SCap 和 SPL）的脂肪浸润（FI）和横截面积（CSA）。根据 Pfirrmann 分级系统，纳入病例中无 I 级。IIr-IV 级病例数分别为 n=16、40、19 和 7。采用 t 检验或单因素方差分析比较颈椎旁肌 CSA 和 FI，Spearman 相关分析评估年龄、椎间盘退变与颈椎旁肌 CSA、FI 的相关性，采用多元线性回归分析 CSA 和 FI 的独立影响因素。
男性患者的颈椎旁肌 CSA 明显高于女性（均 P<0.001），但 FI 无明显差异（均 P>0.05）。年龄与 MF+SCer 的 CSA 呈弱相关，与 SCap 和 SPL 的 CSA 呈中度相关（r=-0.256、-0.355 和-0.361，P<0.05），与 SCap 和 SPL 的 FI 呈弱相关（r=0.182 和 0.264，P<0.001），与 MF+SCer 的 FI 呈中度相关（r=0.408，P<0.001）。FI 与椎间盘退变有显著差异（P<0.001，P=0.028 和 P=0.005）。进一步的相关性分析表明，椎间盘退变与 MF+SCer 的 FI 呈强相关（r=0.629，P<0.001），与 SCap 和 SPL 的 FI 呈中度相关（r=0.363，P=0.001；r=0.345，P=0.002）。多元线性回归分析表明，性别和年龄是 SCap 和 SPL CSA 的影响因素，性别是 MF+SCer CSA 的独立影响因素，椎间盘退变是 FI 的独立影响因素。
年龄与 CSA 呈负相关，与 FI 呈正相关。椎间盘退变与椎旁肌 FI 相关，尤其是与 MF 和 SCer 的 FI 相关。性别和年龄是 CSA 的影响因素，而椎间盘退变是 FI 的独立影响因素。
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