中国成年人早发型和晚发型阿尔茨海默病的行为和心理症状：可改变因素分析
Behavioural and psychological symptoms of early-onset and late-onset Alzheimer's disease among Chinese adults: analysis of modifiable factors.
作者信息
Fang Shuyan, Zhang Shuang, Wang Wenxia, Li Yijing, Zhang Xu, Yu Haisong, Sun Jiao
机构信息
School of Nursing, Jilin University, Changchun, China.
出版信息
Psychogeriatrics. 2022 May;22(3):391-401. doi: 10.1111/psyg.12829. Epub 2022 Mar 28.
BACKGROUND
To conduct a comprehensive comparison of behavioural and psychological symptoms of dementia (BPSD) in Chinese people with early-onset Alzheimer's disease (EOAD) and late-onset Alzheimer's disease (LOAD) and analyse the factors of differences.
METHODS
A cross-sectional survey of 93 EOAD and100 LOAD and their caregivers in China from November 2018 to May 2019.
RESULTS
The total Neuropsychiatric Inventory score was significantly higher in LOAD. A higher level of agitation in EOAD was related to a lower quality of life of caregivers and the emotional expression of ignoring people with dementia. Higher euphoria scores in LOAD were associated with reduced negative coping by caregivers and reduced stability and predictability at home.
CONCLUSION
The early identification and management of specific BPSD of EOAD and LOAD by family members and health professionals may improve the quality of care and life for people with dementia and that of caregivers.
背景
对早发性阿尔茨海默病（EOAD）和晚发性阿尔茨海默病（LOAD）中国患者的痴呆行为和心理症状（BPSD）进行全面比较，并分析差异因素。
方法
2018年11月至2019年5月，对中国93例EOAD患者、100例LOAD患者及其照料者进行横断面调查。
结果
LOAD患者的神经精神科问卷总分显著更高。EOAD患者较高水平的激越与照料者较低的生活质量以及忽视痴呆患者的情感表达有关。LOAD患者较高的欣快感得分与照料者消极应对减少以及家庭稳定性和可预测性降低有关。
结论
家庭成员和健康专业人员对EOAD和LOAD患者特定BPSD的早期识别和管理可能会改善痴呆患者及其照料者的护理质量和生活质量。
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