Zottich Umberto, de Oliveira Isadora Sousa, Fereira Isabela Gobbo, Cerni Felipe Augusto, Karla de Castro Figueiredo Bordon, Arantes Eliane Candiani, Gomes Valdirene Moreira, Dias Germana Bueno, Pucca Manuela Berto
Medical School, Federal University of Roraima, Boa Vista, Roraima, Brazil.
Department of BioMolecular Sciences, School of Pharmaceutical Sciences of Ribeirão Preto, University of São Paulo, Ribeirão Preto, São Paulo, Brazil.
Toxicon X. 2022 Mar 23;14:100120. doi: 10.1016/j.toxcx.2022.100120. eCollection 2022 Jun.
Fungal infections are becoming a serious problem of human diseases, being one of the most important fungal pathogens the yeast of the genus . So far, fungal infection treatment faces different challenges, including the limited number of therapeutic drugs. Scorpions are known to be a valuable source of biologically active molecules, especially of peptide-derived molecules with a variety of biological effects and useful, lead compounds for drugs development. Here, we pioneer described the antifungal effect of venom, mucus, and the major toxin (Rc1) from scorpion. These results support the potential for Rc1 to be further investigated as a novel antifungal therapeutic to treat infections.
真菌感染正成为人类疾病的一个严重问题,酵母属真菌是最重要的真菌病原体之一。到目前为止,真菌感染的治疗面临着不同的挑战,包括治疗药物数量有限。蝎子是生物活性分子的宝贵来源,尤其是具有多种生物效应的肽衍生分子,是药物开发中有用的先导化合物。在这里,我们首次描述了蝎子毒液、黏液和主要毒素(Rc1)的抗真菌作用。这些结果支持了将Rc1作为一种新型抗真菌治疗药物进一步研究以治疗真菌感染的潜力。