Xie Haojun, Yao Hongmei, Huo Yating, Li Ning, Cheng Yuanxiong
Department of Respiratory and Critical Care Medicine, Nanfang Hospital, Southern Medical University, No. 1838 Guangzhou Avenue North, Guangzhou, Guangdong, China.
Tumour Biol. 2014 Oct;35(10):9693-9. doi: 10.1007/s13277-014-2265-6. Epub 2014 Jun 27.
Many studies have investigated the association between tumor necrosis factor alpha (TNF-α) gene 308G/A polymorphism and lung cancer risk, but the results were inconsistent. We thus comprehensively searched the PubMed, EMBASE, and BIOSIS Previews databases and extracted data from all eligible articles to estimate the association between TNF-α gene 308G/A polymorphism and lung cancer risk. The pooled odds ratio (OR) with 95 % confidence intervals (CIs) were calculated. Twelve case-control studies in 11 articles involving 2,436 cases and 2,573 controls were included in the meta-analysis to assess the association between TNF-α gene 308G>A polymorphism and susceptibility to lung cancer. Overall, TNF-α gene 308G>A polymorphism was significantly associated with an increased risk of lung cancer for A vs. G (OR = 1.13, 95 % CI 1.00 ~ 1.27, P = 0.04). Subgroup analysis by ethnicity showed that there was a significant association between TNF-α gene 308G>A polymorphism and increased risk of lung cancer in Asians, but not in Caucasians. In subgroup analysis by tumor type, there were significant associations between TNF-α gene 308G>A polymorphism and increased risk of lung cancer in small cell lung cancer (SCLC) for AA+AG vs. GG, in non-small cell lung cancer (NSCLC) for A vs. G, AA vs. GG, and AA+AG vs. GG. No association between the genotypes and different stages of lung cancer was detected. The meta-analysis suggests that TNF-α gene 308G>A polymorphism is associated with an increased risk of lung cancer, particularly among Asians, both for SCLC and NSCLC, considering tumor type.
许多研究调查了肿瘤坏死因子α（TNF-α）基因308G/A多态性与肺癌风险之间的关联，但结果并不一致。因此，我们全面检索了PubMed、EMBASE和BIOSIS Previews数据库，并从所有符合条件的文章中提取数据，以评估TNF-α基因308G/A多态性与肺癌风险之间的关联。计算了合并比值比（OR）及其95%置信区间（CI）。纳入荟萃分析的11篇文章中的12项病例对照研究涉及2436例病例和2573例对照，以评估TNF-α基因308G>A多态性与肺癌易感性之间的关联。总体而言，TNF-α基因308G>A多态性与A相对于G的肺癌风险增加显著相关（OR = 1.13，95% CI 1.00 ~ 1.27，P = 0.04）。按种族进行的亚组分析表明，TNF-α基因308G>A多态性与亚洲人肺癌风险增加之间存在显著关联，但在白种人中则不然。按肿瘤类型进行的亚组分析中，在小细胞肺癌（SCLC）中，AA + AG相对于GG，在非小细胞肺癌（NSCLC）中，A相对于G、AA相对于GG以及AA + AG相对于GG，TNF-α基因308G>A多态性与肺癌风险增加之间存在显著关联。未检测到基因型与肺癌不同分期之间的关联。荟萃分析表明，考虑肿瘤类型，TNF-α基因308G>A多态性与肺癌风险增加相关，尤其是在亚洲人中，无论是SCLC还是NSCLC。
