Department of Developmental BioEngineering, TechMed Center, University of Twente, Enschede, The Netherlands.
Department of Biomedical Engineering and Institute for Complex Molecular Systems, Eindhoven University of Technology, Eindhoven, The Netherlands.
Tissue Eng Part A. 2022 Jun;28(11-12):542-554. doi: 10.1089/ten.TEA.2021.0215.
In recent years, the mathematical and computational sciences have developed novel methodologies and insights that can aid in designing advanced bioreactors, microfluidic setups or organ-on-chip devices, in optimizing culture conditions, or predicting long-term behavior of engineered tissues . In this review, we introduce the concept of computational models and how they can be integrated in an interdisciplinary workflow for Tissue Engineering and Regenerative Medicine (TERM). We specifically aim this review of general concepts and examples at experimental scientists with little or no computational modeling experience. We also describe the contribution of computational models in understanding TERM processes and in advancing the TERM field by providing novel insights. Impact Statement Although in recent years the use of mathematical and computational sciences has increased in the Tissue Engineering and Regenerative Medicine (TERM) field, we believe that a further integration of experimental and computational approaches has a huge potential for advancing the field due to the ability of models to explain and predict experimental results and efficiently optimize TERM product and process designs. By providing an overview of existing computational models, how they have contributed to the field, as well as a future perspective, this review represents an important step to help realize TERM's ultimate goal: a cure instead of care.
近年来，数学和计算科学已经开发出新颖的方法和见解，可以帮助设计先进的生物反应器、微流控装置或芯片上器官设备，优化培养条件，或预测工程组织的长期行为。在这篇综述中，我们介绍了计算模型的概念，以及它们如何可以集成在组织工程和再生医学（TERM）的跨学科工作流程中。我们特别针对具有很少或没有计算建模经验的实验科学家介绍了一般概念和示例。我们还描述了计算模型在理解 TERM 过程中的贡献，并通过提供新的见解来推动 TERM 领域的发展。
虽然近年来，数学和计算科学在组织工程和再生医学（TERM）领域的应用有所增加，但我们认为，由于模型能够解释和预测实验结果，并有效地优化 TERM 产品和工艺设计，实验和计算方法的进一步结合具有巨大的发展潜力。通过提供对现有计算模型的概述、它们对该领域的贡献以及未来的展望，这篇综述代表了帮助实现 TERM 的最终目标：治疗而非护理的重要一步。
