Loerakker Sandra, Ristori Tommaso
Department of Biomedical Engineering, Eindhoven University of Technology, Groene Loper Building 15, 5612 AP, Eindhoven, the Netherlands.
Institute for Complex Molecular Systems, Eindhoven University of Technology, Groene Loper Building 7, 5612 AJ, Eindhoven, the Netherlands.
Curr Opin Biomed Eng. 2020 Sep;15:1-9. doi: 10.1016/j.cobme.2019.12.007.
Understanding cardiovascular growth and remodeling (G&R) is fundamental for designing robust cardiovascular tissue engineering strategies, which enable synthetic or biological scaffolds to transform into healthy living tissues after implantation. Computational modeling, particularly when integrated with experimental research, is key for advancing our understanding, predicting the evolution of engineered tissues, and efficiently optimizing scaffold designs. As cells are ultimately the drivers of G&R and known to change their behavior in response to mechanical cues, increasing efforts are currently undertaken to capture (mechano-mediated) cell behavior in computational models. In this selective review, we highlight some recent examples that are relevant in the context of cardiovascular tissue engineering and discuss the current and future biological and computational challenges for modeling cell-mediated G&R.
了解心血管生长与重塑（G&R）是设计强大的心血管组织工程策略的基础，这些策略能使合成或生物支架在植入后转化为健康的活组织。计算建模，尤其是与实验研究相结合时，是推动我们的理解、预测工程组织的演变以及有效优化支架设计的关键。由于细胞最终是G&R的驱动因素，并且已知会根据机械信号改变其行为，目前人们正在加大努力在计算模型中捕捉（机械介导的）细胞行为。在这篇选择性综述中，我们重点介绍了一些在心血管组织工程背景下相关的近期实例，并讨论了模拟细胞介导的G&R当前和未来面临的生物学及计算挑战。
