Freshage Research Group, Department of Physiology, Faculty of Medicine, University of Valencia, Centro de Investigación Biomédica en Red Fragilidad y Envejecimiento Saludable-Instituto de Salud Carlos III (CIBERFES-ISCIII), INCLIVA, Valencia, 46010, Spain.
Freshage Research Group, Department of Physiology, Faculty of Medicine, University of Valencia, Centro de Investigación Biomédica en Red Fragilidad y Envejecimiento Saludable-Instituto de Salud Carlos III (CIBERFES-ISCIII), INCLIVA, Valencia, 46010, Spain.
Free Radic Biol Med. 2022 Apr;183:127-137. doi: 10.1016/j.freeradbiomed.2022.03.021. Epub 2022 Mar 26.
Genistein is a phytoestrogen that, due to its structural similarity with estrogen, can both mimic and antagonize estrogen effects. Early analysis proved that at high concentrations, genistein inhibits breast cancer cell proliferation, thereby suggesting an anticancer activity. Since then, many discoveries have identified the genistein mechanism of action, including cell cycle arrest, apoptosis induction, as well as angiogenesis, and metastasis inhibition. In this review, we aim to discuss the multimodal action of genistein as an antioxidant, anti-inflammatory, anti-amyloid β, and autophagy promoter, which could be responsible for the genistein beneficial effect on Alzheimer's. Furthermore, we pinpoint the main signal transduction pathways that are known to be modulated by genistein. Genistein has thus several beneficial effects in several diseases, many of them associated with age, such as the above mentioned Alzheimer disease. Indeed, the beneficial effects of genistein for health promotion depend on each multimodality. In the context of geroscience, genistein has promising beneficial effects due to its multimodal action to treat age associated-diseases.
染料木黄酮是一种植物雌激素，由于其与雌激素的结构相似，既能模拟雌激素的作用，也能拮抗雌激素的作用。早期分析证明，高浓度的染料木黄酮能抑制乳腺癌细胞增殖，从而提示其具有抗癌活性。此后，许多发现确定了染料木黄酮的作用机制，包括细胞周期阻滞、凋亡诱导以及血管生成和转移抑制。在这篇综述中，我们旨在讨论染料木黄酮作为抗氧化剂、抗炎剂、抗淀粉样β和自噬促进剂的多效作用，这可能是染料木黄酮对阿尔茨海默病有益的原因。此外，我们还指出了已知被染料木黄酮调节的主要信号转导通路。因此，染料木黄酮在多种疾病中具有多种有益作用，其中许多与年龄有关，如上述提到的阿尔茨海默病。事实上，染料木黄酮对健康的促进作用的有益效果取决于其多效性。在衰老科学的背景下，由于其多效作用，染料木黄酮有望治疗与年龄相关的疾病。
