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Genistein: a possible solution for the treatment of Alzheimer's disease.

作者信息

Pierzynowska Karolina, Karaszewski Bartosz, Węgrzyn Grzegorz

机构信息

Department of Molecular Biology, University of Gdansk, Gdansk, Poland (Pierzynowska K).

Brain Diseases Centre, Medical University of Gdansk, Poland, and Department of Adult Neurology, Faculty of Medicine, Medical University of Gdansk, Gdansk, Poland (Karaszewski B).

出版信息

Neural Regen Res. 2025 Oct 1;20(10):2903-2905. doi: 10.4103/NRR.NRR-D-24-00713. Epub 2024 Sep 24.

DOI:10.4103/NRR.NRR-D-24-00713
PMID:39610096
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11826469/
Abstract
摘要
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/dbad/11826469/efba0735716c/NRR-20-2903-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/dbad/11826469/8e72a1b9f4e2/NRR-20-2903-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/dbad/11826469/efba0735716c/NRR-20-2903-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/dbad/11826469/8e72a1b9f4e2/NRR-20-2903-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/dbad/11826469/efba0735716c/NRR-20-2903-g002.jpg

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Genistein: a possible solution for the treatment of Alzheimer's disease.金雀异黄素：治疗阿尔茨海默病的一种可能解决方案。
Neural Regen Res. 2025 Oct 1;20(10):2903-2905. doi: 10.4103/NRR.NRR-D-24-00713. Epub 2024 Sep 24.
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Genistein effect on cognition in prodromal Alzheimer's disease patients. The GENIAL clinical trial.金雀异黄素对前驱期阿尔茨海默病患者认知的影响。GENIAL 临床试验。
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Genistein suppresses the mitochondrial apoptotic pathway in hippocampal neurons in rats with Alzheimer's disease.金雀异黄素抑制阿尔茨海默病大鼠海马神经元的线粒体凋亡途径。
Neural Regen Res. 2016 Jul;11(7):1153-8. doi: 10.4103/1673-5374.187056.
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Genistein protects hippocampal neurons against injury by regulating calcium/calmodulin dependent protein kinase IV protein levels in Alzheimer's disease model rats.金雀异黄素通过调节阿尔茨海默病模型大鼠中钙/钙调蛋白依赖性蛋白激酶IV的蛋白水平来保护海马神经元免受损伤。
Neural Regen Res. 2017 Sep;12(9):1479-1484. doi: 10.4103/1673-5374.215260.
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[Effects of the use of 17 β-estradiol and genistein in Alzheimer's disease in women with menopause].[17β-雌二醇和染料木黄酮对绝经后女性阿尔茨海默病的影响]
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Genistein, A Phytoestrogen, Delays the Transition to Dementia in Prodromal Alzheimer's Disease Patients.染料木黄酮，一种植物雌激素，可延缓前驱期阿尔茨海默病患者向痴呆的转变。
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Clearing Amyloid-β through PPARγ/ApoE Activation by Genistein is a Treatment of Experimental Alzheimer's Disease.通过染料木黄酮激活PPARγ/ApoE清除β-淀粉样蛋白是治疗实验性阿尔茨海默病的一种方法。
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Influence of Exercise and Genistein to Mitigate the Deleterious Effects of High-Fat High-Sugar Diet on Alzheimer's Disease-Related Markers in Male Mice.运动和金雀异黄素对减轻高脂肪高糖饮食对雄性小鼠阿尔茨海默病相关标志物的有害影响。
Int J Mol Sci. 2024 Aug 20;25(16):9019. doi: 10.3390/ijms25169019.
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Genistein and Galantamine Combinations Decrease β-Amyloid Peptide -Induced Genotoxicity and Cell Death in SH-SY5Y Cell Line: an In Vitro and In Silico Approach for Mimic of Alzheimer's Disease.金雀异黄素与加兰他敏联合用药可降低β-淀粉样肽诱导的SH-SY5Y细胞系的遗传毒性和细胞死亡：一种模拟阿尔茨海默病的体外和计算机模拟方法
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Front Cell Dev Biol. 2019 Sep 20;7:197. doi: 10.3389/fcell.2019.00197. eCollection 2019.

本文引用的文献

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Gut-brain axis: A cutting-edge approach to target neurological disorders and potential synbiotic application.肠-脑轴：一种针对神经疾病的前沿方法及潜在的合生元应用。
Heliyon. 2024 Jul 4;10(13):e34092. doi: 10.1016/j.heliyon.2024.e34092. eCollection 2024 Jul 15.
2
Beyond amyloid and tau: rethinking Alzheimer's disease through less explored avenues.超越淀粉样蛋白和 tau：通过较少探索的途径重新思考阿尔茨海默病。
Open Biol. 2024 Jun;14(6):240035. doi: 10.1098/rsob.240035. Epub 2024 Jun 12.
3
Genistein: A promising phytoconstituent with reference to its bioactivities.
染料木黄酮：一种具有生物活性的有前途的植物成分。
Phytother Res. 2024 Aug;38(8):3935-3953. doi: 10.1002/ptr.8256. Epub 2024 Jun 3.
4
Epigallocatechin-3-Gallate and Genistein for Decreasing Gut Dysbiosis, Inhibiting Inflammasomes, and Aiding Autophagy in Alzheimer's Disease.表没食子儿茶素-3-没食子酸酯和染料木黄酮用于减少肠道菌群失调、抑制炎性小体及辅助阿尔茨海默病中的自噬作用
Brain Sci. 2024 Jan 19;14(1):96. doi: 10.3390/brainsci14010096.
5
Correction of symptoms of Huntington disease by genistein through FOXO3-mediated autophagy stimulation.金雀异黄素通过 FOXO3 介导的自噬刺激纠正亨廷顿病的症状。
Autophagy. 2024 May;20(5):1159-1182. doi: 10.1080/15548627.2023.2286116. Epub 2023 Nov 27.
6
Genistein effect on cognition in prodromal Alzheimer's disease patients. The GENIAL clinical trial.金雀异黄素对前驱期阿尔茨海默病患者认知的影响。GENIAL 临床试验。
Alzheimers Res Ther. 2022 Nov 4;14(1):164. doi: 10.1186/s13195-022-01097-2.
7
The multimodal action of genistein in Alzheimer's and other age-related diseases.染料木黄酮在阿尔茨海默病和其他与年龄相关疾病中的多模式作用。
Free Radic Biol Med. 2022 Apr;183:127-137. doi: 10.1016/j.freeradbiomed.2022.03.021. Epub 2022 Mar 26.
8
The Unifying Hypothesis of Alzheimer's Disease: Heparan Sulfate Proteoglycans/Glycosaminoglycans Are Key as First Hypothesized Over 30 Years Ago.阿尔茨海默病的统一假说：硫酸乙酰肝素蛋白聚糖/糖胺聚糖如30多年前所首次假设的那样是关键因素。
Front Aging Neurosci. 2021 Oct 4;13:710683. doi: 10.3389/fnagi.2021.710683. eCollection 2021.
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High dose genistein in Sanfilippo syndrome: A randomised controlled trial.高剂量染料木黄酮治疗 Sanfilippo 综合征：一项随机对照试验。
J Inherit Metab Dis. 2021 Sep;44(5):1248-1262. doi: 10.1002/jimd.12407. Epub 2021 Jun 13.
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One drug to treat many diseases: unlocking the economic trap of rare diseases.一种药物治疗多种疾病：破解罕见病的经济困境。
Metab Brain Dis. 2020 Dec;35(8):1237-1240. doi: 10.1007/s11011-020-00617-z. Epub 2020 Sep 14.