Department of Neurology, The Second Hospital of Hebei Medical University, Shijiazhuang, Hebei, China; China National Clinical Research Center for Neurological Diseases, Department of Neurology, Beijing Tiantan Hospital, Capital Medical University, Beijing, China.
Department of Neurology, The Second Hospital of Hebei Medical University, Shijiazhuang, Hebei, China.
Mitochondrion. 2022 May;64:103-111. doi: 10.1016/j.mito.2022.03.004. Epub 2022 Mar 25.
Mitochondrial permeability transition pore (mPTP) is a channel that opens at the inner mitochondrial membrane under conditions of stress. Sirtuin 3 (Sirt3) is a mitochondrial deacetylase known to play a major role in stress resistance and a regulatory role in cell death. This systematic review aims to elucidate the role of Sirt3 in mPTP inhibition. Electronic databases, including PubMed, EMBASE, Web of Science and Cochrane Library were searched up to May 2020. Original studies that investigated the relationship between Sirt3 and mPTP were included. Two reviewers independently extracted data on study characteristics, methods and outcomes. A total of 194 articles were found. Twenty-nine articles, which met criteria were included in the systematic review. Twenty-three studies provided evidence of the inhibitory effect of Sirt3 on the mPTP aperture. This review summarizes up-to-date evidence of the protective and inhibitory role of Sirt3 through deacetylating Cyclophilin D (CypD) on the mPTP aperture. Furthermore, we discuss the implications of this effect in disease.
线粒体通透性转换孔（mPTP）是一种在应激条件下在内膜打开的通道。Sirtuin 3（Sirt3）是一种线粒体去乙酰化酶，已知在应激抵抗中起主要作用，并在细胞死亡中起调节作用。本系统综述旨在阐明 Sirt3 在 mPTP 抑制中的作用。电子数据库，包括 PubMed、EMBASE、Web of Science 和 Cochrane Library，截至 2020 年 5 月进行了检索。纳入了研究 Sirt3 与 mPTP 之间关系的原始研究。两位评审员独立提取了研究特征、方法和结果的数据。共发现 194 篇文章。有 29 篇符合标准的文章被纳入系统综述。23 项研究提供了证据表明 Sirt3 通过去乙酰化环孢素 D（CypD）抑制 mPTP 孔的打开，从而对 mPTP 产生抑制作用。此外，我们还讨论了这种作用在疾病中的意义。
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